Clinical Advancements in the Targeted Therapies against Liver Fibrosis
المؤلفون المشاركون
Bansal, Ruchi
Nagórniewicz, Beata
Prakash, Jai
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-24
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Hepatic fibrosis, characterized by excessive accumulation of extracellular matrix (ECM) proteins leading to liver dysfunction, is a growing cause of mortality worldwide.
Hepatocellular damage owing to liver injury leads to the release of profibrotic factors from infiltrating inflammatory cells that results in the activation of hepatic stellate cells (HSCs).
Upon activation, HSCs undergo characteristic morphological and functional changes and are transformed into proliferative and contractile ECM-producing myofibroblasts.
Over recent years, a number of therapeutic strategies have been developed to inhibit hepatocyte apoptosis, inflammatory responses, and HSCs proliferation and activation.
Preclinical studies have yielded numerous targets for the development of antifibrotic therapies, some of which have entered clinical trials and showed improved therapeutic efficacy and desirable safety profiles.
Furthermore, advancements have been made in the development of noninvasive markers and techniques for the accurate disease assessment and therapy responses.
Here, we focus on the clinical developments attained in the field of targeted antifibrotics for the treatment of liver fibrosis, for example, small molecule drugs, antibodies, and targeted drug conjugate.
We further briefly highlight different noninvasive diagnostic technologies and will provide an overview about different therapeutic targets, clinical trials, endpoints, and translational efforts that have been made to halt or reverse the progression of liver fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bansal, Ruchi& Nagórniewicz, Beata& Prakash, Jai. 2016. Clinical Advancements in the Targeted Therapies against Liver Fibrosis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1111216
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bansal, Ruchi…[et al.]. Clinical Advancements in the Targeted Therapies against Liver Fibrosis. Mediators of Inflammation No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1111216
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bansal, Ruchi& Nagórniewicz, Beata& Prakash, Jai. Clinical Advancements in the Targeted Therapies against Liver Fibrosis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1111216
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111216
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر