![](/images/graphics-bg.png)
Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics
المؤلفون المشاركون
Zorzanelli, Leína
Maeda, Nair Yukie
Clavé, Mariana Meira
Aiello, Vera Demarchi
Rabinovitch, Marlene
Lopes, Antonio Augusto
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background and Objective.
Inflammation is central in the pathogenesis of pulmonary hypertension.
We investigated how serum cytokines correlate with clinical features, hemodynamics, and lung histology in young patients with pulmonary hypertension associated with congenital cardiac shunts.
Design.
Prospective, observational study.
Methods and Results.
Patients ( n = 44 ) were aged 2.6 to 37.6 months.
Group I patients ( n = 31 ) were characterized by pulmonary congestion and higher pulmonary blood flow compared to group II ( p = 0.022 ), with no need for preoperative cardiac catheterization.
Group II patients ( n = 13 ) had no congestive features.
At catheterization, they had elevated pulmonary vascular resistance (5.7 [4.4–7.4] Wood units · m2, geometric mean with 95% CI).
Cytokines were measured by chemiluminescence.
Macrophage migration inhibitory factor (MIF) was found to be inversely related to pulmonary blood flow ( r = - 0.33 , p = 0.026 ) and was higher in group II (high pulmonary vascular resistance) compared to group I (high pulmonary blood flow) ( p = 0.017 ).
In contrast, RANTES chemokine (regulated on activation, normal T cell expressed and secreted) was characteristically elevated in Group I ( p = 0.022 ).
Interleukin 16 was also negatively related to pulmonary blood flow ( r S = - 0.33 , p = 0.029 ) and was higher in patients with obstructive vasculopathy at intraoperative lung biopsy ( p = 0.021 ).
Conclusion.
Cytokines seem to be important and differentially regulated in subpopulations of young patients with cardiac shunts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zorzanelli, Leína& Maeda, Nair Yukie& Clavé, Mariana Meira& Aiello, Vera Demarchi& Rabinovitch, Marlene& Lopes, Antonio Augusto. 2016. Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111219
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zorzanelli, Leína…[et al.]. Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111219
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zorzanelli, Leína& Maeda, Nair Yukie& Clavé, Mariana Meira& Aiello, Vera Demarchi& Rabinovitch, Marlene& Lopes, Antonio Augusto. Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111219
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111219
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)