Periploca forrestii Saponin Ameliorates Murine CFA-Induced Arthritis by Suppressing Cytokine Production
المؤلفون المشاركون
Liu, Yingqin
Li, Minghui
He, Qiuhong
Yang, Xinping
Ruan, Fang
Sun, Guangchen
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Periploca forrestii Schltr.
has been used as a Chinese folk medicine due to its versatile pharmacological effects such as promoting wounds and rheumatoid arthritis.
However, the antiarthritic activity of Periploca forrestii saponin (PFS) and its active compound Periplocin has still not been demonstrated.
Here, we evaluated the antiarthritic effects of PFS in adjuvant-induced arthritis (AIA) rats by intragastric administration at a dose of 50 mg/kg.
The anti-inflammatory activities of Periplocin were also examined in LPS-induced AIA splenocytes and synoviocytes.
PFS significantly ameliorated joint swelling; inhibited bone erosion in joints; lowered levels of IL-6 and TGF-β1 in AIA rat splenocyte; and reduced joint protein expression levels of phospho-STAT3 and IKKα.
Using LPS-induced AIA splenocytes, we demonstrate that Periplocin suppressed the key proinflammatory cytokines levels of IL-6, IFN-γ, TGF-β1, and IL-13 and IL-22 and transcription factor levels of T-bet, GATA3, and C-Jun genes.
Periplocin also suppressed LPS-induced cytokine secretion from synoviocytes.
Our study highlights the antiarthritic activity of PFS and its derived Periplocin and the underlying mechanisms.
These results provide a strong rationale for further testing and validation of the use of Periploca forrestii Schltr.
as an alternative modality for the treatment of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yingqin& Li, Minghui& He, Qiuhong& Yang, Xinping& Ruan, Fang& Sun, Guangchen. 2016. Periploca forrestii Saponin Ameliorates Murine CFA-Induced Arthritis by Suppressing Cytokine Production. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111229
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yingqin…[et al.]. Periploca forrestii Saponin Ameliorates Murine CFA-Induced Arthritis by Suppressing Cytokine Production. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111229
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yingqin& Li, Minghui& He, Qiuhong& Yang, Xinping& Ruan, Fang& Sun, Guangchen. Periploca forrestii Saponin Ameliorates Murine CFA-Induced Arthritis by Suppressing Cytokine Production. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111229
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111229
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر