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The Association of High Prevalence of Trophozoites in Peripheral Blood with Lower Antibody Response to P. falciparum Infected Erythrocytes among Asymptomatic Children in Sudan
المؤلفون المشاركون
Ibrahim, Muntasir E.
Mohamed, Sara N.
Hassan, Dina A.
El Hussein, Abdelrahim M.
Mohamed, Hiba S.
Nour, Bakri Y.
Abdulhadi, Nasreldin H.
Osman, Ihsan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-28
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
The most prominent variant surface antigens (VSAs) of Plasmodium falciparum are the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family, which serves as a parasite-sequestering ligand to endothelial cells.
In this study we have examined the antibody reactivity of autologous plasma from symptomatic and asymptomatic malaria infected children against the infected erythrocytes’ surface antigens using flow cytometry.
Methods.
Ethidium-bromide-labelled erythrocytic mature forms of P.
falciparum parasites obtained from symptomatic and asymptomatic children were sequentially incubated with autologous plasma and fluorescein isothiocyanate-conjugated (FITC) antihuman IgG.
Plasma antibody reactivity was detected by flow cytometry.
Results.
Asymptomatic children had more prevalence of trophozoites in peripheral blood (66%) compared to symptomatic children (16%), p = 0.002 .
The mean percentage of infected RBCs reacting with autologous sera was 89.78 among symptomatic children compared to 79.62 among asymptomatic children ( p = 0.09 ).
Moreover, the mean fluorescence intensity (MFI) in the asymptomatic was significantly higher compared to symptomatic children ( p value = 0.040).
Conclusion.
Variant surface antigens on Plasmodium falciparum infected RBCs from symptomatic malaria children tend to be better recognized by IgG antibodies.
This may suggest a role of some IgG antibodies in severity of malaria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohamed, Sara N.& Hassan, Dina A.& El Hussein, Abdelrahim M.& Osman, Ihsan& Ibrahim, Muntasir E.& Mohamed, Hiba S.…[et al.]. 2016. The Association of High Prevalence of Trophozoites in Peripheral Blood with Lower Antibody Response to P. falciparum Infected Erythrocytes among Asymptomatic Children in Sudan. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1111235
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohamed, Sara N.…[et al.]. The Association of High Prevalence of Trophozoites in Peripheral Blood with Lower Antibody Response to P. falciparum Infected Erythrocytes among Asymptomatic Children in Sudan. Mediators of Inflammation No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1111235
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohamed, Sara N.& Hassan, Dina A.& El Hussein, Abdelrahim M.& Osman, Ihsan& Ibrahim, Muntasir E.& Mohamed, Hiba S.…[et al.]. The Association of High Prevalence of Trophozoites in Peripheral Blood with Lower Antibody Response to P. falciparum Infected Erythrocytes among Asymptomatic Children in Sudan. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1111235
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111235
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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