Effects of Chinese Propolis in Protecting Bovine Mammary Epithelial Cells against Mastitis Pathogens-Induced Cell Damage
المؤلفون المشاركون
Wang, Kai
Wu, Liming
Jin, Xiao-Lu
Shen, Xiao-Ge
Sun, Li-Ping
Wei, Jiang-Qin
Marcucci, Maria Cristina
Liu, Jian-Xin
Hu, Fuliang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Chinese propolis (CP), an important hive product, can alleviate inflammatory responses.
However, little is known regarding the potential of propolis treatment for mastitis control.
To investigate the anti-inflammatory effects of CP on bovine mammary epithelial cells (MAC-T), we used a range of pathogens to induce cellular inflammatory damage.
Cell viability was determined and expressions of inflammatory/antioxidant genes were measured.
Using a cell-based reporter assay system, we evaluated CP and its primary constituents on the NF-κB and Nrf2-ARE transcription activation.
MAC-T cells treated with bacterial endotoxin (lipopolysaccharide, LPS), heat-inactivated Escherichia coli, and Staphylococcus aureus exhibited significant decreases in cell viability while TNF-α and lipoteichoic acid (LTA) did not.
Pretreatment with CP prevented losses in cell viability associated with the addition of killed bacteria or bacterial endotoxins.
There were also corresponding decreases in expressions of proinflammatory IL-6 and TNF-α mRNA.
Compared with the mastitis challenged cells, enhanced expressions of antioxidant genes HO-1, Txnrd-1, and GCLM were observed in CP-treated cells.
CP and its polyphenolic active components (primarily caffeic acid phenethyl ester and quercetin) had strong inhibitive effects against NF-κB activation and increased the transcriptional activity of Nrf2-ARE.
These findings suggest that propolis may be valuable in the control of bovine mastitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Kai& Jin, Xiao-Lu& Shen, Xiao-Ge& Sun, Li-Ping& Wu, Liming& Wei, Jiang-Qin…[et al.]. 2016. Effects of Chinese Propolis in Protecting Bovine Mammary Epithelial Cells against Mastitis Pathogens-Induced Cell Damage. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111238
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Kai…[et al.]. Effects of Chinese Propolis in Protecting Bovine Mammary Epithelial Cells against Mastitis Pathogens-Induced Cell Damage. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111238
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Kai& Jin, Xiao-Lu& Shen, Xiao-Ge& Sun, Li-Ping& Wu, Liming& Wei, Jiang-Qin…[et al.]. Effects of Chinese Propolis in Protecting Bovine Mammary Epithelial Cells against Mastitis Pathogens-Induced Cell Damage. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111238
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111238
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر