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Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy
المؤلفون المشاركون
Liao, Sui-Ling
Lai, Shen-Hao
Tsai, Ming-Han
Hua, Man-Chin
Yeh, Kuo-Wei
Su, Kuan-Wen
Chiang, Chi-Hsin
Huang, Shih-Yin
Kao, Chuan-Chi
Yao, Tsung-Chieh
Huang, Jing-Long
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited.
The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome.
Maternal and cord blood 25 (OH)D level were examined from 372 maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed.
Clinical outcomes related to infection at 12 months of age were also evaluated.
The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient.
There was a high correlation between maternal and cord 25(OH)D levels ( r = 0.67 , p < 0.001 ).
Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 ( p = 0.004 ) and TLR7-8 stimulation ( p = 0.006 ).
However, none of the TLR-triggered cytokine productions were associated with cord 25(OH)D concentration.
There was no relationship between maternal and cord blood vitamin D status with infectious diseases during infancy.
In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liao, Sui-Ling& Lai, Shen-Hao& Tsai, Ming-Han& Hua, Man-Chin& Yeh, Kuo-Wei& Su, Kuan-Wen…[et al.]. 2016. Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liao, Sui-Ling…[et al.]. Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liao, Sui-Ling& Lai, Shen-Hao& Tsai, Ming-Han& Hua, Man-Chin& Yeh, Kuo-Wei& Su, Kuan-Wen…[et al.]. Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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