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Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties
المؤلفون المشاركون
Oyedeji, Opeoluwa O.
Oyedeji, Adebola O.
Rali, Sibusiso
Aremu, Olukayode O.
Nkeh-Chungag, Benedicta N.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Oleanolic acid is a pentacyclic triterpenoid compound widely found in plants and well known for its medicinal properties.
Oleanolic acid (OA) was isolated from the ethyl acetate extract of Syzygium aromaticum flower buds.
Semisynthesis afforded both acetate and ester derivatives.
The derived compounds were monitored with thin layer chromatography and confirmed with nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), Fourier infrared (FT-IR) spectroscopy, and melting point (Mp).
All these compounds were evaluated for their analgesic and anti-inflammatory properties at a dose of 40 mg/kg.
Significant analgesic and anti-inflammatory effects were noted for all OA-derived compounds.
In the formalin-induced pain test, the derivatives showed better analgesic effects compared to their precursor, whereas, in the tale flick test, oleanolic acid proved to be superior in analgesic effects compared to all its derivatives with the exception of the acetyl derivative.
Acute inflammatory tests showed that acetyl derivatives possessed better anti-inflammatory activity compared to the other compounds.
In conclusion, semisynthesis of oleanolic acid yielded several derivatives with improved solubility and enhanced analgesic and anti-inflammatory properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rali, Sibusiso& Oyedeji, Opeoluwa O.& Aremu, Olukayode O.& Oyedeji, Adebola O.& Nkeh-Chungag, Benedicta N.. 2016. Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111256
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rali, Sibusiso…[et al.]. Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111256
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rali, Sibusiso& Oyedeji, Opeoluwa O.& Aremu, Olukayode O.& Oyedeji, Adebola O.& Nkeh-Chungag, Benedicta N.. Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111256
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111256
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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