Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis
المؤلفون المشاركون
Chao Wei, Chen
Qi Ping, Dai
Tian You, Fan
Yong Qiang, Chen
Tao, Che
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim.
Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis.
However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation.
Methods.
New Zealand rabbits were immunized with antigen-induced arthritis (AIA) and treated with icariin.
Joint tissues from rabbits were studied by histological analysis, transmission electron microscopy (TEM), and micro-CT.
The expression levels of receptor activator of nuclear factor-B ligand (RANKL) and osteoprotegerin (OPG) in joint tissues were determined using immunohistochemistry and real-time PCR analysis.
Results.
Histological analysis and TEM sections of cartilage in the ICA treated group showed a low level of chondrocyte destruction.
Micro-CT analysis showed that the bone mineral density value and bone structural level in ICA treated rabbits were significantly higher compared with those in the AIA group.
Immunohistochemistry and real-time PCR analysis showed that icariin treatment reduced RANKL expression and enhanced OPG expression levels, as compared to the AIA group.
Conclusion.
These data indicate that ICA suppresses articular bone loss and prevents joint destruction.
This study also determined that ICA regulated articular bone loss in part by regulating RANKL and OPG expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chao Wei, Chen& Qi Ping, Dai& Tian You, Fan& Yong Qiang, Chen& Tao, Che. 2016. Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chao Wei, Chen…[et al.]. Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chao Wei, Chen& Qi Ping, Dai& Tian You, Fan& Yong Qiang, Chen& Tao, Che. Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111309
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر