Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine
المؤلفون المشاركون
Vicente-Rodríguez, Marta
Fernández-Calle, Rosalía
Gramage, Esther
Pérez-García, Carmen
Ramos, María P.
Herradón, Gonzalo
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Midkine (MK) is a cytokine that modulates amphetamine-induced striatal astrogliosis, suggesting a possible role of MK in neuroinflammation induced by amphetamine.
To test this hypothesis, we studied astrogliosis and microglial response induced by amphetamine (10 mg/kg i.p.
four times, every 2 h) in different brain areas of MK−/− mice and wild type (WT) mice.
We found that amphetamine-induced microgliosis and astrocytosis are enhanced in the striatum of MK−/− mice in a region-specific manner.
Surprisingly, LPS-induced astrogliosis in the striatum was blocked in MK−/− mice.
Since striatal neuroinflammation induced by amphetamine-type stimulants correlates with the cognitive deficits induced by these drugs, we also tested the long-term effects of periadolescent amphetamine treatment (3 mg/kg i.p.
daily for 10 days) in a memory task in MK−/− and WT mice.
Significant deficits in the Y-maze test were only observed in amphetamine-pretreated MK−/− mice.
The data demonstrate for the first time that MK is a novel modulator of neuroinflammation depending on the inflammatory stimulus and the brain area considered.
The data indicate that MK limits amphetamine-induced striatal neuroinflammation.
In addition, our data demonstrate that periadolescent amphetamine treatment in mice results in transient disruption of learning and memory processes in absence of endogenous MK.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vicente-Rodríguez, Marta& Fernández-Calle, Rosalía& Gramage, Esther& Pérez-García, Carmen& Ramos, María P.& Herradón, Gonzalo. 2016. Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vicente-Rodríguez, Marta…[et al.]. Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vicente-Rodríguez, Marta& Fernández-Calle, Rosalía& Gramage, Esther& Pérez-García, Carmen& Ramos, María P.& Herradón, Gonzalo. Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر