Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis
المؤلفون المشاركون
Comi, G. C.
Furlan, Roberto
Dalla Costa, Gloria
Moiola, Lucia
Colombo, Bruno
Martinelli, Vittorio
Passerini, Gabriella
Sangalli, Francesca
Locatelli, Massimo
المصدر
Multiple Sclerosis International
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
The presence of CSF oligoclonal bands (OBs) is an independent prognostic factor for multiple sclerosis (MS), but the difficulties in the standardization of the test and the interlaboratory variation in reporting have contributed to its limited use in the diagnosis of the disease.
Standard nephelometric assays to measure free light chains (FLC) levels have been recently developed and the test may improve the detection of intrathecal B cells activity.
Methods.
The presence of OBs, kappa and lambda FLC levels, and standard indices of intrathecal inflammation were assessed in 100 consecutive patients, including patients with MS, clinically isolated syndromes (CIS), other inflammatory diseases of the CNS, and other noninflammatory diseases.
Results.
Both KFLC and LFLC correlated strongly with the presence of OCBs and with all common tests for intrathecal inflammation (p<0.001 for all comparisons).
KFLC and LFLC were significantly different in patients with MS and CIS compared to the other groups (p<0.001 and p<0.001, resp.) and had a better diagnostic accuracy than all the other tests (area under the curve 82.3 % for KFLC index and 79.3 % for LFLC index).
Conclusion.
Nephelometric assays for KFLC in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate MS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Passerini, Gabriella& Dalla Costa, Gloria& Sangalli, Francesca& Moiola, Lucia& Colombo, Bruno& Locatelli, Massimo…[et al.]. 2016. Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis. Multiple Sclerosis International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1112948
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Passerini, Gabriella…[et al.]. Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis. Multiple Sclerosis International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1112948
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Passerini, Gabriella& Dalla Costa, Gloria& Sangalli, Francesca& Moiola, Lucia& Colombo, Bruno& Locatelli, Massimo…[et al.]. Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis. Multiple Sclerosis International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1112948
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1112948
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر