Electroacupuncture Treatment Alleviates Central Poststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant Astrocyte Activation
المؤلفون المشاركون
Chen, Jianxin
Li, You-Ping
Tao, Shan-Shan
Chen, Man-Tang
Li, Yu-Sang
Shang, Hong-Cai
Tang, Xiao-Yi
Tang, He-Bin
Tian, Gui-Hua
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Electroacupuncture (EA) is reported to effectively relieve the central poststroke pain (CPSP).
However, the underlying mechanism remains unclear.
The present study investigated the detailed mechanisms of action of EA treatment at different frequencies for CPSP.
A CPSP model was established with a single collagenase injection to the left ventral posterolateral nucleus of the thalamus.
The EA-treated groups then received EA treatment at frequency of 2, 2/15, or 15 Hz for 30 min daily for five days.
The pain-related behavioral responses, neuronal apoptosis, glial activation, and the expression of pain signal transmission-related factors (β-catenin, COX-2, and NK-1R) were assessed using behavioral tests, Nissl staining, TUNEL staining, and immunohistochemical staining, respectively.
The low-frequency EA treatment significantly (1) reduced brain tissue damage and hematoma sizes and (2) inhibited neuronal apoptosis, thereby exerting abirritative effects.
Meanwhile, the high-frequency EA treatment induced a greater inhibition of the aberrant astrocyte activation, accompanied by the downregulation of the expressions of COX-2, β-catenin, and subsequently NK-1R, thereby alleviating inflammation and producing strong analgesic effects.
Together, these findings suggest that CPSP is closely related to pathological changes of the neocortex and hippocampus.
EA treatments at different frequencies may exert abirritative effects by inhibiting brain neuronal apoptosis and aberrant astrocyte activation in the brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Gui-Hua& Tao, Shan-Shan& Chen, Man-Tang& Li, Yu-Sang& Li, You-Ping& Shang, Hong-Cai…[et al.]. 2016. Electroacupuncture Treatment Alleviates Central Poststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant Astrocyte Activation. Neural Plasticity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1112972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Gui-Hua…[et al.]. Electroacupuncture Treatment Alleviates Central Poststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant Astrocyte Activation. Neural Plasticity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1112972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Gui-Hua& Tao, Shan-Shan& Chen, Man-Tang& Li, Yu-Sang& Li, You-Ping& Shang, Hong-Cai…[et al.]. Electroacupuncture Treatment Alleviates Central Poststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant Astrocyte Activation. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1112972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1112972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر