Pairing Cholinergic Enhancement with Perceptual Training Promotes Recovery of Age-Related Changes in Rat Primary Auditory Cortex
المؤلفون المشاركون
de Villers-Sidani, Etienne
Voss, Patrice
Thomas, Maryse
Chou, You Chien
Cisneros-Franco, José Miguel
Ouellet, Lydia
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-29
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
We used the rat primary auditory cortex (A1) as a model to probe the effects of cholinergic enhancement on perceptual learning and auditory processing mechanisms in both young and old animals.
Rats learned to perform a two-tone frequency discrimination task over the course of two weeks, combined with either the administration of a cholinesterase inhibitor or saline.
We found that while both age groups learned the task more quickly through cholinergic enhancement, the young did so by improving target detection, whereas the old did so by inhibiting erroneous responses to nontarget stimuli.
We also found that cholinergic enhancement led to marked functional and structural changes within A1 in both young and old rats.
Importantly, we found that several functional changes observed in the old rats, particularly those relating to the processing and inhibition of nontargets, produced cortical processing features that resembled those of young untrained rats more so than those of older adult rats.
Overall, these findings demonstrate that combining auditory training with neuromodulation of the cholinergic system can restore many of the auditory cortical functional deficits observed as a result of normal aging and add to the growing body of evidence demonstrating that many age-related perceptual and neuroplastic changes are reversible.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Voss, Patrice& Thomas, Maryse& Chou, You Chien& Cisneros-Franco, José Miguel& Ouellet, Lydia& de Villers-Sidani, Etienne. 2015. Pairing Cholinergic Enhancement with Perceptual Training Promotes Recovery of Age-Related Changes in Rat Primary Auditory Cortex. Neural Plasticity،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1112988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Voss, Patrice…[et al.]. Pairing Cholinergic Enhancement with Perceptual Training Promotes Recovery of Age-Related Changes in Rat Primary Auditory Cortex. Neural Plasticity No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1112988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Voss, Patrice& Thomas, Maryse& Chou, You Chien& Cisneros-Franco, José Miguel& Ouellet, Lydia& de Villers-Sidani, Etienne. Pairing Cholinergic Enhancement with Perceptual Training Promotes Recovery of Age-Related Changes in Rat Primary Auditory Cortex. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1112988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1112988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر