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Spatiotemporal Expression and Molecular Characterization of miR-344b and miR-344c in the Developing Mouse Brain
المؤلفون المشاركون
Leong, Jia-Wen
Ling, King-Hwa
Cheah, Pike-See
Abdullah, Syahril
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-01
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) are small noncoding RNA known to regulate brain development.
The expression of two novel miRNAs, namely, miR-344b and miR-344c, was characterized during mouse brain developmental stages in this study.
In situ hybridization analysis showed that miR-344b and miR-344c were expressed in the germinal layer during embryonic brain developmental stages.
In contrast, miR-344b was not detectable in the adult brain while miR-344c was expressed exclusively in the adult olfactory bulb and cerebellar granular layer.
Stem-loop RT-qPCR analysis of whole brain RNAs showed that expression of the miR-344b and miR-344c was increased as brain developed throughout the embryonic stage and maintained at adulthood.
Further investigation showed that these miRNAs were expressed in adult organs, where miR-344b and miR-344c were highly expressed in pancreas and brain, respectively.
Bioinformatics analysis suggested miR-344b and miR-344c targeted Olig2 and Otx2 mRNAs, respectively.
However, luciferase experiments demonstrated that these miRNAs did not target Olig2 and Otx2 mRNAs.
Further investigation on the locality of miR-344b and miR-344c showed that both miRNAs were localized in nuclei of immature neurons.
In conclusion, miR-344b and miR-344c were expressed spatiotemporally during mouse brain developmental stages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leong, Jia-Wen& Abdullah, Syahril& Ling, King-Hwa& Cheah, Pike-See. 2016. Spatiotemporal Expression and Molecular Characterization of miR-344b and miR-344c in the Developing Mouse Brain. Neural Plasticity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113008
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leong, Jia-Wen…[et al.]. Spatiotemporal Expression and Molecular Characterization of miR-344b and miR-344c in the Developing Mouse Brain. Neural Plasticity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113008
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leong, Jia-Wen& Abdullah, Syahril& Ling, King-Hwa& Cheah, Pike-See. Spatiotemporal Expression and Molecular Characterization of miR-344b and miR-344c in the Developing Mouse Brain. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113008
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113008
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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