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Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease
المؤلفون المشاركون
Kanjhan, Refik
Noakes, Peter G.
Bellingham, Mark C.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-31، 31ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-30
دولة النشر
مصر
عدد الصفحات
31
التخصصات الرئيسية
الملخص EN
Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks.
At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia and spines.
Consistent with Vaughn’s synaptotropic hypothesis, we propose a developmental unified-hybrid model implicating filopodia in motoneuron spinogenesis/synaptogenesis and dendritic growth and branching critical for circuit formation and synaptic plasticity at embryonic/prenatal/neonatal period.
Filopodia density decreases and spine density initially increases until postnatal day 15 (P15) and then decreases by P30.
Spine distribution shifts towards the distal dendrites, and spines become shorter (stubby), coinciding with decreases in frequency and increases in amplitude of excitatory postsynaptic currents with maturation.
In transgenic mice, either overexpressing the mutated human Cu/Zn-superoxide dismutase ( hSOD 1 G 93 A ) gene or deficient in GABAergic/glycinergic synaptic transmission (gephyrin, GAD-67, or VGAT gene knockout), hypoglossal motoneurons develop excitatory glutamatergic synaptic hyperactivity.
Functional synaptic hyperactivity is associated with increased dendritic growth, branching, and increased spine and filopodia density, involving actin-based cytoskeletal and structural remodelling.
Energy-dependent ionic pumps that maintain intracellular sodium/calcium homeostasis are chronically challenged by activity and selectively overwhelmed by hyperactivity which eventually causes sustained membrane depolarization leading to excitotoxicity, activating microglia to phagocytose degenerating neurons under neuropathological conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kanjhan, Refik& Noakes, Peter G.& Bellingham, Mark C.. 2015. Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-31.
https://search.emarefa.net/detail/BIM-1113075
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kanjhan, Refik…[et al.]. Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease. Neural Plasticity No. 2016 (2016), pp.1-31.
https://search.emarefa.net/detail/BIM-1113075
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kanjhan, Refik& Noakes, Peter G.& Bellingham, Mark C.. Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-31.
https://search.emarefa.net/detail/BIM-1113075
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113075
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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