Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate
المؤلفون المشاركون
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-04
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Several important discoveries in growth cone cell biology were made possible by the use of growth cones derived from cultured Aplysia bag cell neurons, including the characterization of the organization and dynamics of the cytoskeleton.
The majority of these Aplysia studies focused on large growth cones induced by poly-L-lysine substrates at early stages in cell culture.
Under these conditions, the growth cones are in a steady state with very little net advancement.
Here, we offer a comprehensive cellular analysis of the motile behavior of Aplysia growth cones in culture beyond this pausing state.
We found that average growth cone size decreased with cell culture time whereas average growth rate increased.
This inverse correlation of growth rate and growth cone size was due to the occurrence of large growth cones with a peripheral domain larger than 100 μm2.
The large pausing growth cones had central domains that were less consistently aligned with the direction of growth and could be converted into smaller, faster-growing growth cones by addition of a three-dimensional collagen gel.
We conclude that the significant lateral expansion of lamellipodia and filopodia as observed during these culture conditions has a negative effect on neurite growth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ren, Yuan& Suter, Daniel M.. 2016. Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ren, Yuan& Suter, Daniel M.. Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ren, Yuan& Suter, Daniel M.. Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر