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The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex
المؤلفون المشاركون
Gruz-Gibelli, Emmanuelle
Chessel, Natacha
Allioux, Clélia
Marin, Pascale
Piotton, Françoise
Leuba, Geneviève
Savioz, Armand
Herrmann, François R.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The amyloid-β peptide or Aβ is the key player in the amyloid-cascade hypothesis of Alzheimer’s disease.
Aβ appears to trigger cell death but also production of double-strand breaks (DSBs) in aging and Alzheimer’s disease.
All-trans retinoic acid (RA), a derivative of vitamin A, was already known for its neuroprotective effects against the amyloid cascade.
It diminishes, for instance, the production of Aβ peptides and their oligomerisation.
In the present work we investigated the possible implication of RA receptor (RAR) in repair of Aβ-induced DSBs.
We demonstrated that RA, as well as RAR agonist Am80, but not AGN 193109 antagonist, repair Aβ-induced DSBs in SH-SY5Y cells and an astrocytic cell line as well as in the murine cortical tissue of young and aged mice.
The nonhomologous end joining pathway and the Ataxia Telangiectasia Mutated kinase were shown to be involved in RA-mediated DSBs repair in the SH-SY5Y cells.
Our data suggest that RA, besides increasing cell viability in the cortex of young and even of aged mice, might also result in targeted DNA repair of genes important for cell or synaptic maintenance.
This phenomenon would remain functional up to a point when Aβ increase and RA decrease probably lead to a pathological state.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gruz-Gibelli, Emmanuelle& Chessel, Natacha& Allioux, Clélia& Marin, Pascale& Piotton, Françoise& Leuba, Geneviève…[et al.]. 2016. The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gruz-Gibelli, Emmanuelle…[et al.]. The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gruz-Gibelli, Emmanuelle& Chessel, Natacha& Allioux, Clélia& Marin, Pascale& Piotton, Françoise& Leuba, Geneviève…[et al.]. The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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