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Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk
المؤلفون المشاركون
Zhang, Jianye
Wang, Junjie
Tang, Yingying
Zhang, Tianhong
Cui, Huiru
Xu, Lihua
Zeng, Botao
Li, Yu
Li, Gaiying
Li, Chunbo
Liu, Hui
Lu, Zheng
Wang, Jijun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia.
However, it remains unclear how these abnormalities impact the onset and course of psychosis.
In the present study, 21 drug-naïve subjects at ultrahigh risk for psychosis (UHR), 16 drug-naïve patients with first-episode schizophrenia (FES), and 23 healthy controls (HC) were enrolled.
In vivo GABA and glutamate+glutamine (Glx) levels in the medial prefrontal cortex were measured using proton magnetic resonance spectroscopy.
Medial prefrontal GABA and Glx levels in FES patients were significantly lower than those in HC and UHR, respectively.
GABA and Glx levels in UHR were comparable with those in HC.
In each group, there was a positive correlation between GABA and Glx levels.
Reduced medial prefrontal GABA and Glx levels thus may play an important role in the early stages of schizophrenia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Junjie& Tang, Yingying& Zhang, Tianhong& Cui, Huiru& Xu, Lihua& Zeng, Botao…[et al.]. 2016. Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113114
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Junjie…[et al.]. Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113114
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Junjie& Tang, Yingying& Zhang, Tianhong& Cui, Huiru& Xu, Lihua& Zeng, Botao…[et al.]. Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113114
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113114
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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