![](/images/graphics-bg.png)
Anger Emotional Stress Influences VEGFVEGFR2 and Its Induced PI3KAKTmTOR Signaling Pathway
المؤلفون المشاركون
Wei, Sheng
Sun, Peng
Wei, Xia
Wang, Jieqiong
Zhang, Yuanyuan
Wu, Jibiao
Qiao, Mingqi
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
We discuss the influence of anger emotional stress upon VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway.
Methods.
We created a rat model of induced anger (anger-out and anger-in) emotional response using social isolation and resident-intruder paradigms and assessed changes in hippocampus’ VEGF content, neuroplasticity, and the PI3K/AKT/mTOR signaling pathway.
Results.
The resident-intruder method successfully generated anger-out and anger-in models that differed significantly in composite aggression score, aggression incubation, open field behavior, sucrose preference, and weight gain.
Anger emotional stress decreased synaptic connections and VEGFR2 expression.
Anger emotional stress led to abnormal expression of VEGF/VEGFR2 mRNA and protein and disorderly expression of key factors in the PI3K/AKT/mTOR signal pathway.
Fluoxetine administration ameliorated behavioral abnormalities and damage to hippocampal neurons caused by anger emotional stress, as well as abnormal expression of some proteins in VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway.
Conclusion.
This research provides a detailed classification of anger emotion and verifies its influence upon VEGF and the VEGF-induced signaling pathway, thus providing circumstantial evidence of mechanisms by which anger emotion damages neurogenesis.
As VEGFR2 can promote neurogenesis and vasculogenesis in the hippocampus and frontal lobe, these results suggest that anger emotional stress can result in decreased neurogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Peng& Wei, Sheng& Wei, Xia& Wang, Jieqiong& Zhang, Yuanyuan& Qiao, Mingqi…[et al.]. 2016. Anger Emotional Stress Influences VEGFVEGFR2 and Its Induced PI3KAKTmTOR Signaling Pathway. Neural Plasticity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113128
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Peng…[et al.]. Anger Emotional Stress Influences VEGFVEGFR2 and Its Induced PI3KAKTmTOR Signaling Pathway. Neural Plasticity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113128
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Peng& Wei, Sheng& Wei, Xia& Wang, Jieqiong& Zhang, Yuanyuan& Qiao, Mingqi…[et al.]. Anger Emotional Stress Influences VEGFVEGFR2 and Its Induced PI3KAKTmTOR Signaling Pathway. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113128
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113128
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)