Transcriptomic Modification in the Cerebral Cortex following Noninvasive Brain Stimulation: RNA-Sequencing Approach
المؤلفون المشاركون
Holmes, Ben
Jung, Seung Ho
Lu, Jing
Wagner, Jessica A.
Rubbi, Liudmilla
Pellegrini, Matteo
Jankord, Ryan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-29
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Transcranial direct current stimulation (tDCS) has been shown to modulate neuroplasticity.
Beneficial effects are observed in patients with psychiatric disorders and enhancement of brain performance in healthy individuals has been observed following tDCS.
However, few studies have attempted to elucidate the underlying molecular mechanisms of tDCS in the brain.
This study was conducted to assess the impact of tDCS on gene expression within the rat cerebral cortex.
Anodal tDCS was applied at 3 different intensities followed by RNA-sequencing and analysis.
In each current intensity, approximately 1,000 genes demonstrated statistically significant differences compared to the sham group.
A variety of functional pathways, biological processes, and molecular categories were found to be modified by tDCS.
The impact of tDCS on gene expression was dependent on current intensity.
Results show that inflammatory pathways, antidepressant-related pathways (GTP signaling, calcium ion binding, and transmembrane/signal peptide pathways), and receptor signaling pathways (serotonergic, adrenergic, GABAergic, dopaminergic, and glutamate) were most affected.
Of the gene expression profiles induced by tDCS, some changes were observed across multiple current intensities while other changes were unique to a single stimulation intensity.
This study demonstrates that tDCS can modify the expression profile of various genes in the cerebral cortex and that these tDCS-induced alterations are dependent on the current intensity applied.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Holmes, Ben& Jung, Seung Ho& Lu, Jing& Wagner, Jessica A.& Rubbi, Liudmilla& Pellegrini, Matteo…[et al.]. 2016. Transcriptomic Modification in the Cerebral Cortex following Noninvasive Brain Stimulation: RNA-Sequencing Approach. Neural Plasticity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113200
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holmes, Ben…[et al.]. Transcriptomic Modification in the Cerebral Cortex following Noninvasive Brain Stimulation: RNA-Sequencing Approach. Neural Plasticity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113200
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Holmes, Ben& Jung, Seung Ho& Lu, Jing& Wagner, Jessica A.& Rubbi, Liudmilla& Pellegrini, Matteo…[et al.]. Transcriptomic Modification in the Cerebral Cortex following Noninvasive Brain Stimulation: RNA-Sequencing Approach. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113200
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113200
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر