Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease
المؤلفون المشاركون
Cao, Lei-Fang
Peng, Xiao-Yan
Huang, Ya
Wang, Bing
Zhou, Feng-Ming
Cheng, Ruo-Xiao
Chen, Li-Hua
Luo, Wei-Feng
Liu, Tong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-26
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu).
PD rats developed thermal and mechanical hypersensitivity at the 4th week after surgery.
HPLC analysis showed that NE content, but not dopamine or 5-HT, significantly decreased in lumbar spinal cord in PD rats.
Additional noradrenergic depletion by injection of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) aggravated pain hypersensitivity in PD rats.
At the 5th week after injection of 6-OHDA, systemic treatment with pharmacological norepinephrine (NE) precursor droxidopa (L-DOPS) or α 2 adrenoceptor agonist clonidine significantly attenuated thermal and mechanical pain hypersensitivity in PD rats.
Furthermore, application of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) reuptake inhibitors duloxetine, but not 5-HT selective reuptake inhibitors sertraline, significantly inhibited thermal and mechanical pain hypersensitivity in PD rats.
Systemic administration of Madopar (L-DOPA) or the D2/D3 agonist pramipexole slightly inhibited the thermal, but not mechanical, hypersensitivity in PD rats.
Thus, our study revealed that impairment of descending noradrenergic system may play a key role in PD-associated pain and restoring spinal noradrenergic inhibitory tone may serve as a novel strategy to manage PD-associated pain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Lei-Fang& Peng, Xiao-Yan& Huang, Ya& Wang, Bing& Zhou, Feng-Ming& Cheng, Ruo-Xiao…[et al.]. 2016. Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Lei-Fang…[et al.]. Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease. Neural Plasticity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Lei-Fang& Peng, Xiao-Yan& Huang, Ya& Wang, Bing& Zhou, Feng-Ming& Cheng, Ruo-Xiao…[et al.]. Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر