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Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease
المؤلفون المشاركون
Cao, Lei-Fang
Peng, Xiao-Yan
Huang, Ya
Wang, Bing
Zhou, Feng-Ming
Cheng, Ruo-Xiao
Chen, Li-Hua
Luo, Wei-Feng
Liu, Tong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-26
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu).
PD rats developed thermal and mechanical hypersensitivity at the 4th week after surgery.
HPLC analysis showed that NE content, but not dopamine or 5-HT, significantly decreased in lumbar spinal cord in PD rats.
Additional noradrenergic depletion by injection of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) aggravated pain hypersensitivity in PD rats.
At the 5th week after injection of 6-OHDA, systemic treatment with pharmacological norepinephrine (NE) precursor droxidopa (L-DOPS) or α 2 adrenoceptor agonist clonidine significantly attenuated thermal and mechanical pain hypersensitivity in PD rats.
Furthermore, application of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) reuptake inhibitors duloxetine, but not 5-HT selective reuptake inhibitors sertraline, significantly inhibited thermal and mechanical pain hypersensitivity in PD rats.
Systemic administration of Madopar (L-DOPA) or the D2/D3 agonist pramipexole slightly inhibited the thermal, but not mechanical, hypersensitivity in PD rats.
Thus, our study revealed that impairment of descending noradrenergic system may play a key role in PD-associated pain and restoring spinal noradrenergic inhibitory tone may serve as a novel strategy to manage PD-associated pain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Lei-Fang& Peng, Xiao-Yan& Huang, Ya& Wang, Bing& Zhou, Feng-Ming& Cheng, Ruo-Xiao…[et al.]. 2016. Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Lei-Fang…[et al.]. Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease. Neural Plasticity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Lei-Fang& Peng, Xiao-Yan& Huang, Ya& Wang, Bing& Zhou, Feng-Ming& Cheng, Ruo-Xiao…[et al.]. Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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