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Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster
المؤلفون المشاركون
Majeed, Zana R.
Abdeljaber, Esraa
Soveland, Robin
Cornwell, Kristin
Bankemper, Aubrey
Koch, Felicitas
Cooper, R. L.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-17
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
Serotonin modulates various physiological processes and behaviors.
This study investigates the role of 5-HT in locomotion and feeding behaviors as well as in modulation of sensory-motor circuits.
The 5-HT biosynthesis was dysregulated by feeding Drosophila larvae 5-HT, a 5-HT precursor, or an inhibitor of tryptophan hydroxylase during early stages of development.
The effects of feeding fluoxetine, a selective serotonin reuptake inhibitor, during early second instars were also examined.
5-HT receptor subtypes were manipulated using RNA interference mediated knockdown and 5-HT receptor insertional mutations.
Moreover, synaptic transmission at 5-HT neurons was blocked or enhanced in both larvae and adult flies.
The results demonstrate that disruption of components within the 5-HT system significantly impairs locomotion and feeding behaviors in larvae.
Acute activation of 5-HT neurons disrupts normal locomotion activity in adult flies.
To determine which 5-HT receptor subtype modulates the evoked sensory-motor activity, pharmacological agents were used.
In addition, the activity of 5-HT neurons was enhanced by expressing and activating TrpA1 channels or channelrhodopsin-2 while recording the evoked excitatory postsynaptic potentials (EPSPs) in muscle fibers.
5-HT2 receptor activation mediates a modulatory role in a sensory-motor circuit, and the activation of 5-HT neurons can suppress the neural circuit activity, while fluoxetine can significantly decrease the sensory-motor activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Majeed, Zana R.& Abdeljaber, Esraa& Soveland, Robin& Cornwell, Kristin& Bankemper, Aubrey& Koch, Felicitas…[et al.]. 2016. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plasticity،Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1113266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Majeed, Zana R.…[et al.]. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plasticity No. 2016 (2016), pp.1-23.
https://search.emarefa.net/detail/BIM-1113266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Majeed, Zana R.& Abdeljaber, Esraa& Soveland, Robin& Cornwell, Kristin& Bankemper, Aubrey& Koch, Felicitas…[et al.]. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1113266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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