Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function

المؤلفون المشاركون

Stockburger, Carola
Miano, Davide
Pallas, Thea
Friedland, Kristina
Müller, Walter E.

المصدر

Neural Plasticity

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-09-26

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأحياء
الطب البشري

الملخص EN

The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer’s disease.

Accordingly, improving mitochondrial function has become an important strategy to treat the early stages of this continuum.

The metabolic enhancer piracetam has been proposed as possible prototype for those compounds by increasing impaired mitochondrial function and related aspects like mechanisms of neuroplasticity.

We here report that piracetam at therapeutically relevant concentrations improves neuritogenesis in the human cell line SH-SY5Y over conditions mirroring the whole spectrum of age-associated cognitive decline.

These effects go parallel with improvement of impaired mitochondrial dynamics shifting back fission and fusion balance to the energetically more favorable fusion site.

Impaired fission and fusion balance can also be induced by a reduction of the mitochondrial permeability transition pore (mPTP) function as atractyloside which indicates the mPTP has similar effects on mitochondrial dynamics.

These changes are also reduced by piracetam.

These findings suggest the mPTP as an important target for the beneficial effects of piracetam on mitochondrial function.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Stockburger, Carola& Miano, Davide& Pallas, Thea& Friedland, Kristina& Müller, Walter E.. 2016. Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function. Neural Plasticity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113310

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Stockburger, Carola…[et al.]. Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function. Neural Plasticity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113310

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Stockburger, Carola& Miano, Davide& Pallas, Thea& Friedland, Kristina& Müller, Walter E.. Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113310

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1113310