Assessment of the Central Effects of Natural Uranium via Behavioural Performances and the Cerebrospinal Fluid Metabolome
المؤلفون المشاركون
Grison, Stéphane
Favé, G.
Elie, C.
Dhieux, B.
Martin, J. C.
Tack, K.
Lestaevel, Philippe
Souidi, Maâmar
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Natural uranium (NU), a component of the earth’s crust, is not only a heavy metal but also an alpha particle emitter, with chemical and radiological toxicity.
Populations may therefore be chronically exposed to NU through drinking water and food.
Since the central nervous system is known to be sensitive to pollutants during its development, we assessed the effects on the behaviour and the cerebrospinal fluid (CSF) metabolome of rats exposed for 9 months from birth to NU via lactation and drinking water (1.5, 10, or 40 mg·L−1 for male rats and 40 mg·L−1 for female rats).
Medium-term memory decreased in comparison to controls in male rats exposed to 1.5, 10, or 40 mg·L−1 NU.
In male rats, spatial working memory and anxiety- and depressive-like behaviour were only altered by exposure to 40 mg·L−1 NU and any significant effect was observed on locomotor activity.
In female rats exposed to NU, only locomotor activity was significantly increased in comparison with controls.
LC-MS metabolomics of CSF discriminated the fingerprints of the male and/or female NU-exposed and control groups.
This study suggests that exposure to environmental doses of NU from development to adulthood can have an impact on rat brain function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lestaevel, Philippe& Grison, Stéphane& Favé, G.& Elie, C.& Dhieux, B.& Martin, J. C.…[et al.]. 2016. Assessment of the Central Effects of Natural Uranium via Behavioural Performances and the Cerebrospinal Fluid Metabolome. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lestaevel, Philippe…[et al.]. Assessment of the Central Effects of Natural Uranium via Behavioural Performances and the Cerebrospinal Fluid Metabolome. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lestaevel, Philippe& Grison, Stéphane& Favé, G.& Elie, C.& Dhieux, B.& Martin, J. C.…[et al.]. Assessment of the Central Effects of Natural Uranium via Behavioural Performances and the Cerebrospinal Fluid Metabolome. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر