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Chronic Alcohol Intoxication and Cortical Ischemia: Study of Their Comorbidity and the Protective Effects of Minocycline
المؤلفون المشاركون
Fontes-Júnior, Enéas Andrade
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Gomes-Leal, Walace
Costa-Malaquias, Allan
Lima, Rafael Rodrigues
Prediger, Rui Daniel
Crespo-López, Maria Elena
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chronic alcohol intoxication (CAI) increases both morbidity and mortality of stroke patients.
Despite the high prevalence of CAI and ischemic stroke, studies addressing their comorbidity and/or protective alternatives remain scarce.
Thus, the influence of CAI on both stroke outcome and minocycline treatment (recognized for its neuroprotective effect) was investigated.
Female Wistar rats (35 days old) were treated with water or ethanol (6.5 g/kg/day, 22.5% w/v) for 55 days.
Then, focal ischemia was induced by endothelin-1 in the motor cortex.
Two hours later, four doses of 50 mg/kg of minocycline every 12 hours followed by five doses of 25 mg/kg every 24 hours were administered.
Behavioral performance (open field and rotarod tests) and immunohistochemical (cellular density, neuronal death, and astrocytic activation) and biochemical (lipid peroxidation and nitrite levels) analyses were performed.
CAI increased motor disruption, nitrite and lipid peroxidation levels, and neuronal loss caused by ischemia, whereas it reduced the astrogliosis.
Minocycline was effective in preventing the motor and tissue damage caused by stroke.
However, these effects were attenuated when CAI preceded stroke.
Our data suggest that CAI beginning in adolescence contributes to a worse outcome in ischemic stroke survivors and reduces the benefits of minocycline, possibly requiring adjustments in therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fontes-Júnior, Enéas Andrade& Maia, Cristiane Socorro Ferraz& Fernandes, Luanna Melo Pereira& Gomes-Leal, Walace& Costa-Malaquias, Allan& Lima, Rafael Rodrigues…[et al.]. 2016. Chronic Alcohol Intoxication and Cortical Ischemia: Study of Their Comorbidity and the Protective Effects of Minocycline. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113606
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fontes-Júnior, Enéas Andrade…[et al.]. Chronic Alcohol Intoxication and Cortical Ischemia: Study of Their Comorbidity and the Protective Effects of Minocycline. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113606
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fontes-Júnior, Enéas Andrade& Maia, Cristiane Socorro Ferraz& Fernandes, Luanna Melo Pereira& Gomes-Leal, Walace& Costa-Malaquias, Allan& Lima, Rafael Rodrigues…[et al.]. Chronic Alcohol Intoxication and Cortical Ischemia: Study of Their Comorbidity and the Protective Effects of Minocycline. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113606
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113606
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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