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Effect of Cross-Sex Hormonal Replacement on Antioxidant Enzymes in Rat Retroperitoneal Fat Adipocytes
المؤلفون المشاركون
Zuñiga-Muñoz, Alejandra
Guarner Lans, Verónica
Pérez-Torres, Israel
Velázquez Espejel, Rodrigo
Cabrera-Orefice, Alfredo
Uribe-Carvajal, Salvador
Pavón, Natalia
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We report the effect of cross-sex hormonal replacement on antioxidant enzymes from rat retroperitoneal fat adipocytes.
Eight rats of each gender were assigned to each of the following groups: control groups were intact female or male (F and M, resp.).
Experimental groups were ovariectomized F (OvxF), castrated M (CasM), OvxF plus testosterone (OvxF + T), and CasM plus estradiol (CasM + E2) groups.
After sacrifice, retroperitoneal fat was dissected and processed for histology.
Adipocytes were isolated and the following enzymatic activities were determined: Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and glutathione reductase (GR).
Also, glutathione (GSH) and lipid peroxidation (LPO) were measured.
In OvxF, retroperitoneal fat increased and adipocytes were enlarged, while in CasM rats a decrease in retroperitoneal fat and small adipocytes are observed.
The cross-sex hormonal replacement in F rats was associated with larger adipocytes and a further decreased activity of Cu-Zn SOD, CAT, GPx, GST, GR, and GSH, in addition to an increase in LPO.
CasM + E2 exhibited the opposite effects showing further activation antioxidant enzymes and decreases in LPO.
In conclusion, E2 deficiency favors an increase in retroperitoneal fat and large adipocytes.
Cross-sex hormonal replacement in F rats aggravates the condition by inhibiting antioxidant enzymes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pérez-Torres, Israel& Guarner Lans, Verónica& Zuñiga-Muñoz, Alejandra& Velázquez Espejel, Rodrigo& Cabrera-Orefice, Alfredo& Uribe-Carvajal, Salvador…[et al.]. 2016. Effect of Cross-Sex Hormonal Replacement on Antioxidant Enzymes in Rat Retroperitoneal Fat Adipocytes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113621
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pérez-Torres, Israel…[et al.]. Effect of Cross-Sex Hormonal Replacement on Antioxidant Enzymes in Rat Retroperitoneal Fat Adipocytes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113621
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pérez-Torres, Israel& Guarner Lans, Verónica& Zuñiga-Muñoz, Alejandra& Velázquez Espejel, Rodrigo& Cabrera-Orefice, Alfredo& Uribe-Carvajal, Salvador…[et al.]. Effect of Cross-Sex Hormonal Replacement on Antioxidant Enzymes in Rat Retroperitoneal Fat Adipocytes. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113621
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113621
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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