Impact of Oxidative Stress in Premature Aging and Iron Overload in Hemodialysis Patients
المؤلفون المشاركون
Solorio-Meza, Sergio
Murillo-Ortiz, Blanca
Ramírez Emiliano, Joel
Hernández Vázquez, Wendy Ivett
Martínez-Garza, Sandra
Albarrán-Tamayo, Froylán
Ramos-Rodríguez, Edna
Benítez- Bribiesca, Luis
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Increased oxidative stress is a well described feature of patients in hemodialysis.
Their need for multiple blood transfusions and supplemental iron causes a significant iron overload that has recently been associated with increased oxidation of polyunsaturated lipids and accelerated aging due to DNA damage caused by telomere shortening.
Methods.
A total of 70 patients were evaluated concomitantly, 35 volunteers with ferritin levels below 500 ng/mL (Group A) and 35 volunteers with ferritin levels higher than 500 ng/mL (Group B).
A sample of venous blood was taken to extract DNA from leukocytes and to measure relative telomere length by real-time PCR.
Results.
Patients in Group B had significantly higher plasma TBARS (p=0.008), carbonyls (p=0.0004), and urea (p=0.02) compared with those in Group A.
Telomeres were significantly shorter in Group B, 0.66 (SD, 0.051), compared with 0.75 (SD, 0.155) in Group A (p=0.0017).
We observed a statistically significant association between relative telomere length and ferritin levels (r=-0.37, p=0.001).
Relative telomere length was inversely related to time on hemodialysis (r=-0.27, p=0.02).
Conclusions.
Our findings demonstrate that iron overload was associated with increased levels of oxidative stress and shorter relative telomere length.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Murillo-Ortiz, Blanca& Ramírez Emiliano, Joel& Hernández Vázquez, Wendy Ivett& Martínez-Garza, Sandra& Solorio-Meza, Sergio& Albarrán-Tamayo, Froylán…[et al.]. 2016. Impact of Oxidative Stress in Premature Aging and Iron Overload in Hemodialysis Patients. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113630
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Murillo-Ortiz, Blanca…[et al.]. Impact of Oxidative Stress in Premature Aging and Iron Overload in Hemodialysis Patients. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113630
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Murillo-Ortiz, Blanca& Ramírez Emiliano, Joel& Hernández Vázquez, Wendy Ivett& Martínez-Garza, Sandra& Solorio-Meza, Sergio& Albarrán-Tamayo, Froylán…[et al.]. Impact of Oxidative Stress in Premature Aging and Iron Overload in Hemodialysis Patients. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113630
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113630
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر