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The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and CEBPβ rather than Enterotoxigenic Bacteroides fragilis Infection
المؤلفون المشاركون
Kudryavtseva, Anna V.
Alekseev, Boris Y.
Kaprin, Andrey D.
Snezhkina, Anastasiya V.
Lipatova, Anastasiya V.
Sadritdinova, Asiya F.
Kardymon, Olga L.
Fedorova, Maria S.
Stepanov, Oleg A.
Zaretsky, Andrew R.
Dmitriev, Alexey A.
Melnikova, Nataliya V.
Krasnov, George S.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Colorectal cancer is one of the most common cancers in the world.
It is well known that the chronic inflammation can promote the progression of colorectal cancer (CRC).
Recently, a number of studies revealed a potential association between colorectal inflammation, cancer progression, and infection caused by enterotoxigenic Bacteroides fragilis (ETBF).
Bacterial enterotoxin activates spermine oxidase (SMO), which produces spermidine and H2O2 as byproducts of polyamine catabolism, which, in turn, enhances inflammation and tissue injury.
Using qPCR analysis, we estimated the expression of SMOX gene and ETBF colonization in CRC patients.
We found no statistically significant associations between them.
Then we selected genes involved in polyamine metabolism, metabolic reprogramming, and inflammation regulation and estimated their expression in CRC.
We observed overexpression of SMOX, ODC1, SRM, SMS, MTAP, c-Myc, C/EBPβ (CREBP), and other genes.
We found that two mediators of metabolic reprogramming, inflammation, and cell proliferation c-Myc and C/EBPβ may serve as regulators of polyamine metabolism genes (SMOX, AZIN1, MTAP, SRM, ODC1, AMD1, and AGMAT) as they are overexpressed in tumors, have binding site according to ENCODE ChIP-Seq data, and demonstrate strong coexpression with their targets.
Thus, increased polyamine metabolism in CRC could be driven by c-Myc and C/EBPβ rather than ETBF infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Snezhkina, Anastasiya V.& Krasnov, George S.& Lipatova, Anastasiya V.& Sadritdinova, Asiya F.& Kardymon, Olga L.& Fedorova, Maria S.…[et al.]. 2016. The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and CEBPβ rather than Enterotoxigenic Bacteroides fragilis Infection. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Snezhkina, Anastasiya V.…[et al.]. The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and CEBPβ rather than Enterotoxigenic Bacteroides fragilis Infection. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Snezhkina, Anastasiya V.& Krasnov, George S.& Lipatova, Anastasiya V.& Sadritdinova, Asiya F.& Kardymon, Olga L.& Fedorova, Maria S.…[et al.]. The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and CEBPβ rather than Enterotoxigenic Bacteroides fragilis Infection. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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