Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia
المؤلفون المشاركون
Badran, Mohammad
Ayas, Najib
Abuyassin, Bisher
Golbidi, Saeid
Laher, Ismail
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is often present in diabetic (DB) patients.
Both conditions are associated with endothelial dysfunction and cardiovascular disease.
We hypothesized that diabetic endothelial dysfunction is further compromised by CIH.
Methods.
Adult male diabetic (BKS.Cg-Dock7m +/+ Leprdb/J) (db/db) mice (10 weeks old) and their heterozygote littermates were subjected to CIH or intermittent air (IA) for 8 weeks.
Mice were separated into 4 groups: IA (intermittent air nondiabetic), IH (intermittent hypoxia nondiabetic), IADB (intermittent air diabetic), and IHDB (intermittent hypoxia diabetic) groups.
Endothelium-dependent and endothelium-independent relaxation and modulation by basal nitric oxide (NO) were analyzed using wire myograph.
Plasma 8-isoprostane, interleukin-6 (IL-6), and asymmetric dimethylarginine (ADMA) were measured using ELISA.
Uncoupling of eNOS was measured using dihydroethidium (DHE) staining.
Results.
Endothelium-dependent vasodilation and basal NO production were significantly impaired in the IH and IADB group compared to IA group but was more pronounced in IHDB group.
Levels of 8-isoprostane, IL-6, ADMA, and eNOS uncoupling were ≈2-fold higher in IH and IADB groups and were further increased in the IHDB group.
Conclusion.
Endothelial dysfunction is more pronounced in diabetic mice subjected to CIH compared to diabetic or CIH mice alone.
Oxidative stress, ADMA, and eNOS uncoupling were exacerbated by CIH in diabetic mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Badran, Mohammad& Abuyassin, Bisher& Golbidi, Saeid& Ayas, Najib& Laher, Ismail. 2016. Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113695
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Badran, Mohammad…[et al.]. Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113695
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Badran, Mohammad& Abuyassin, Bisher& Golbidi, Saeid& Ayas, Najib& Laher, Ismail. Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113695
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113695
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر