HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation
المؤلفون المشاركون
Lin, Shenglan
Wang, Yana
Zhang, Xiaojin
Kong, Qiuyue
Li, Chuanfu
Li, Yuehua
Ding, Zhengnian
Liu, Li
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Aging-induced cardiac dysfunction is a prominent feature of cardiac aging.
Heat shock protein 27 (HSP27) protects cardiac function against ischemia or chemical challenge.
We hypothesized that HSP27 attenuates cardiac aging.
Transgenic (Tg) mice with cardiac-specific expression of the HSP27 gene and wild-type (WT) littermates were employed in the experiments.
Echocardiography revealed a significant decline in the cardiac function of old WT mice compared with young WT mice.
In striking contrast, the aging-induced impairment of cardiac function was attenuated in old Tg mice compared with old WT mice.
Levels of cardiac aging markers were lower in old Tg mouse hearts than in old WT mouse hearts.
Less interstitial fibrosis and lower contents of reactive oxygen species and ubiquitin-conjugated proteins were detected in old Tg hearts than in old WT hearts.
Furthermore, old Tg hearts demonstrated lower accumulation of LC3-II and p62 than old WT hearts.
Levels of Atg13, Vps34, and Rab7 were also higher in old Tg hearts than in old WT hearts.
Additionally, old Tg hearts had higher levels of PINK1 and Parkin than old WT hearts, suggesting that mitophagy was activated in old Tg hearts.
Taken together, HSP27 alleviated cardiac aging and this action involved antioxidation and mitophagy activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Shenglan& Wang, Yana& Zhang, Xiaojin& Kong, Qiuyue& Li, Chuanfu& Li, Yuehua…[et al.]. 2016. HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113726
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Shenglan…[et al.]. HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113726
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Shenglan& Wang, Yana& Zhang, Xiaojin& Kong, Qiuyue& Li, Chuanfu& Li, Yuehua…[et al.]. HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113726
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113726
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر