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Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
المؤلفون المشاركون
Garrick, Jacqueline M.
Pellacani, Claudia
Roque, Pamela
Costa, Lucio Guido
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Increasing interest has recently focused on determining whether several natural compounds, collectively referred to as nutraceuticals, may exert neuroprotective actions in the developing, adult, and aging nervous system.
Quercetin, a polyphenol widely present in nature, has received the most attention in this regard.
Several studies in vitro, in experimental animals and in humans, have provided supportive evidence for neuroprotective effects of quercetin, either against neurotoxic chemicals or in various models of neuronal injury and neurodegenerative diseases.
The exact mechanisms of such protective effects remain elusive, though many hypotheses have been formulated.
In addition to a possible direct antioxidant effect, quercetin may also act by stimulating cellular defenses against oxidative stress.
Two such pathways include the induction of Nrf2-ARE and induction of the antioxidant/anti-inflammatory enzyme paraoxonase 2 (PON2).
In addition, quercetin has been shown to activate sirtuins (SIRT1), to induce autophagy, and to act as a phytoestrogen, all mechanisms by which quercetin may provide its neuroprotection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Costa, Lucio Guido& Garrick, Jacqueline M.& Roque, Pamela& Pellacani, Claudia. 2016. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113760
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Costa, Lucio Guido…[et al.]. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113760
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Costa, Lucio Guido& Garrick, Jacqueline M.& Roque, Pamela& Pellacani, Claudia. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113760
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113760
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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