Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NOcGMP Pathways and Rho-Associated Kinases Expression
المؤلفون المشاركون
Chen, Bi-Cheng
He, Yunqiang
Xu, Ziqiang
Xia, Peng
Jin, Hao
Zhang, Yan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Transplant arteriosclerosis is considered one of the major factors affecting the survival time of grafts after organ transplantation.
In this study, we proposed a hypothesis of whether lycopene can protect grafted vessels through regulating key proteins expression involved in arteriosclerosis.
Methods.
Allogeneic aortic transplantation was performed using Brow-Norway rats as donors and Lewis rats as recipients.
After transplantation, the recipients were divided into two groups: the allograft group and the lycopene group.
Negative control rats (isograft group) were also established.
Histopathological staining was performed to observe the pathological changes, and the expression levels of Ki-67, caspase-3, Rho-associated kinases, intercellular adhesion molecules (ICAM-1), and eNOS were assessed.
Western blotting analysis and real-time PCR were also performed for quantitative analysis.
Results.
The histopathological staining showed that vascular stenosis and intimal thickening were not evident after lycopene treatment.
The Ki-67, ROCK1, ROCK2, and ICAM-1 expression levels were significantly decreased.
However, eNOS expression in grafted arteries and plasma cGMP concentration were increased after lycopene treatment.
Conclusions.
Lycopene could alleviate vascular arteriosclerosis in allograft transplantation via downregulating Rho-associated kinases and regulating key factor expression through the NO/cGMP pathways, which may provide a potentially effective method for transplant arteriosclerosis in clinical organ transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Yunqiang& Xia, Peng& Jin, Hao& Zhang, Yan& Chen, Bi-Cheng& Xu, Ziqiang. 2016. Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NOcGMP Pathways and Rho-Associated Kinases Expression. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Yunqiang…[et al.]. Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NOcGMP Pathways and Rho-Associated Kinases Expression. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Yunqiang& Xia, Peng& Jin, Hao& Zhang, Yan& Chen, Bi-Cheng& Xu, Ziqiang. Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NOcGMP Pathways and Rho-Associated Kinases Expression. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر