Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies
المؤلفون المشاركون
Guimarães-Santos, Adriano
Santos, Ijair Rogério
Gomes-Leal, Walace
Fernandes, Luanna Melo Pereira
Lima, Rafael Rodrigues
Santana, Luana N. S.
Fernandes, Rafael M.
Nascimento, Elder M.
Oliveira, Ana Carolina A.
Santos, Enio Mauricio N. dos
Tavares, Patrycy Assis N.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-05
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Stroke is a leading cause of death and neurological disability worldwide and striatal ischemic stroke is frequent in humans due to obstruction of middle cerebral artery.
Several pathological events underlie damage progression and a comprehensive description of the pathological features following experimental stroke in both acute and chronic survival times is a necessary step for further functional studies.
Here, we explored the patterns of microglial activation, astrocytosis, oligodendrocyte damage, myelin impairment, and Nogo-A immunoreactivity between 3 and 30 postlesion days (PLDs) after experimental striatal stroke in adult rats induced by microinjections of endothelin-1 (ET-1).
The focal ischemia induced tissue loss concomitant with intense microglia activation between 3 and 14 PLDs (maximum at 7 PLDs), decreasing afterward.
Astrocytosis was maximum around 7 PLDs.
Oligodendrocyte damage and Nogo-A upregulation were higher at 3 PLDs.
Myelin impairment was maximum between 7 and 14 PLDs.
Nogo-A expression was higher in the first week in comparison to control.
The results add important histopathological features of ET-1 induced stroke in subacute and chronic survival times.
In addition, the establishment of the temporal evolution of these neuropathological events is an important step for future studies seeking suitable neuroprotective drugs targeting neuroinflammation and white matter damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lima, Rafael Rodrigues& Santana, Luana N. S.& Fernandes, Rafael M.& Nascimento, Elder M.& Oliveira, Ana Carolina A.& Fernandes, Luanna Melo Pereira…[et al.]. 2016. Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lima, Rafael Rodrigues…[et al.]. Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lima, Rafael Rodrigues& Santana, Luana N. S.& Fernandes, Rafael M.& Nascimento, Elder M.& Oliveira, Ana Carolina A.& Fernandes, Luanna Melo Pereira…[et al.]. Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر