Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy
المؤلفون المشاركون
Jiang, Tingting
Chang, Qing
Cai, Jiyang
Fan, Jiawen
Zhang, Xiaozhe
Xu, Gezhi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-06
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Oxidative stress and inflammation are important pathogenic factors contributing to the etiology of diabetic retinopathy (DR).
Melatonin is an endogenous hormone that exhibits a variety of biological effects including antioxidant and anti-inflammatory functions.
The goals of this study were to determine whether melatonin could ameliorate retinal injury and to explore the potential mechanisms.
Diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (60 mg/kg) in Sprague-Dawley rats.
Melatonin (10 mg kg−1 daily, i.p.) was administered from the induction of diabetes and continued for up to 12 weeks, after which the animals were sacrificed and retinal samples were collected.
The retina of diabetic rats showed depletion of glutathione and downregulation of glutamate cysteine ligase (GCL).
Melatonin significantly upregulated GCL by retaining Nrf2 in the nucleus and stimulating Akt phosphorylation.
The production of proinflammatory cytokines and proteins, including interleukin 1β, TNF-α, and inducible nitric oxide synthase (iNOS), was inhibited by melatonin through the NF-κB pathway.
At 12 weeks, melatonin prevented the significant decrease in the ERG a- and b-wave amplitudes under the diabetic condition.
Our results suggest potent protective functions of melatonin in diabetic retinopathy.
In addition to being a direct antioxidant, melatonin can exert receptor-mediated signaling effects to attenuate inflammation and oxidative stress of the retina.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Tingting& Chang, Qing& Cai, Jiyang& Fan, Jiawen& Zhang, Xiaozhe& Xu, Gezhi. 2016. Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113823
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Tingting…[et al.]. Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113823
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Tingting& Chang, Qing& Cai, Jiyang& Fan, Jiawen& Zhang, Xiaozhe& Xu, Gezhi. Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113823
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113823
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر