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PD98059 Protects Brain against Cells Death Resulting from ROSERK Activation in a Cardiac Arrest Rat Model
المؤلفون المشاركون
Chen, Meng-Hua
Nguyen Thi, Phuong Anh
Li, Nuo
Zhuo, Xiao-Jun
Xie, Lu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-16
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The clinical and experimental postcardiac arrest treatment has not reached therapeutic success.
The present study investigated the effect of PD98059 (PD) in rats subjected to cardiac arrest (CA)/cardiopulmonary resuscitation (CPR).
Experimental rats were divided randomly into 3 groups: sham, CA, and PD.
The rats except for sham group were subjected to CA for 5 min followed by CPR operation.
Once spontaneous circulation was restored, saline and PD were injected in CA and PD groups, respectively.
The survival rates and neurologic deficit scores (NDS) were observed, and the following indices of brain tissue were evaluated: ROS, MDA, SOD, p-ERK1/2/ERK1/2, caspase-3, Bax, Bcl-2, TUNEL positive cells, and double fluorescent staining of p-ERK/TUNEL.
Our results indicated that PD treatment significantly reduced apoptotic neurons and improved the survival rates and NDS.
Moreover, PD markedly downregulated the ROS, MDA, p-ERK, and caspase-3, Bax and upregulated SOD and Bcl-2 levels.
Double staining p-ERK/TUNEL in choroid plexus and cortex showed that cell death is dependent on ERK activation.
The findings in present study demonstrated that PD provides neuroprotection via antioxidant activity and antiapoptosis in rats subjected to CA/CPR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nguyen Thi, Phuong Anh& Chen, Meng-Hua& Li, Nuo& Zhuo, Xiao-Jun& Xie, Lu. 2016. PD98059 Protects Brain against Cells Death Resulting from ROSERK Activation in a Cardiac Arrest Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nguyen Thi, Phuong Anh…[et al.]. PD98059 Protects Brain against Cells Death Resulting from ROSERK Activation in a Cardiac Arrest Rat Model. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nguyen Thi, Phuong Anh& Chen, Meng-Hua& Li, Nuo& Zhuo, Xiao-Jun& Xie, Lu. PD98059 Protects Brain against Cells Death Resulting from ROSERK Activation in a Cardiac Arrest Rat Model. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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