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Phlorizin, an Active Ingredient of Eleutherococcus senticosus, Increases Proliferative Potential of Keratinocytes with Inhibition of MiR135b and Increased Expression of Type IV Collagen
المؤلفون المشاركون
Choi, Hye-Ryung
Kim, Young-Soo
Nam, Kyung-Mi
Lee, Hyun-Sun
Yang, Seung-Hye
Date, Akira
Toyama, Kazumi
Park, Kyoung-Chan
Lee, Jongsung
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
E.
senticosus extract (ESE), known as antioxidant, has diverse pharmacologic effects.
It is also used as an antiaging agent for the skin and phlorizin (PZ) is identified as a main ingredient.
In this study, the effects of PZ on epidermal stem cells were investigated.
Cultured normal human keratinocytes and skin equivalents are used to test whether PZ affects proliferative potential of keratinocytes and how it regulates these effects.
Skin equivalents (SEs) were treated with ESE and the results showed that the epidermis became slightly thickened on addition of 0.002% ESE.
The staining intensity of p63 as well as proliferating cell nuclear antigen (PCNA) is increased, and integrin α6 was upregulated.
Analysis of ESE confirmed that PZ is the main ingredient.
When SEs were treated with PZ, similar findings were observed.
In particular, the expression of integrin α6, integrin β1, and type IV collagen was increased.
Levels of mRNA for type IV collagen were increased and levels of miR135b were downregulated.
All these findings suggested that PZ can affect the proliferative potential of epidermal cells in part by microenvironment changes via miR135b downregulation and following increased expression of type IV collagen.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Hye-Ryung& Nam, Kyung-Mi& Lee, Hyun-Sun& Yang, Seung-Hye& Kim, Young-Soo& Lee, Jongsung…[et al.]. 2016. Phlorizin, an Active Ingredient of Eleutherococcus senticosus, Increases Proliferative Potential of Keratinocytes with Inhibition of MiR135b and Increased Expression of Type IV Collagen. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Hye-Ryung…[et al.]. Phlorizin, an Active Ingredient of Eleutherococcus senticosus, Increases Proliferative Potential of Keratinocytes with Inhibition of MiR135b and Increased Expression of Type IV Collagen. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Hye-Ryung& Nam, Kyung-Mi& Lee, Hyun-Sun& Yang, Seung-Hye& Kim, Young-Soo& Lee, Jongsung…[et al.]. Phlorizin, an Active Ingredient of Eleutherococcus senticosus, Increases Proliferative Potential of Keratinocytes with Inhibition of MiR135b and Increased Expression of Type IV Collagen. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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