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Parishin from Gastrodia elata Extends the Lifespan of Yeast via Regulation of Sir2Uth1TOR Signaling Pathway
المؤلفون المشاركون
Lin, Yanfei
Sun, Yujuan
Weng, Yufang
Matsuura, Akira
Xiang, Lan
Qi, Jianhua
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Parishin is a phenolic glucoside isolated from Gastrodia elata, which is an important traditional Chinese medicine; this glucoside significantly extended the replicative lifespan of K6001 yeast at 3, 10, and 30 μM.
To clarify its mechanism of action, assessment of oxidative stress resistance, superoxide dismutase (SOD) activity, malondialdehyde (MDA), and reactive oxygen species (ROS) assays, replicative lifespans of sod1, sod2, uth1, and skn7 yeast mutants, and real-time quantitative PCR (RT-PCR) analysis were conducted.
The significant increase of cell survival rate in oxidative stress condition was observed in parishin-treated groups.
Silent information regulator 2 (Sir2) gene expression and SOD activity were significantly increased after treating parishin in normal condition.
Meanwhile, the levels of ROS and MDA in yeast were significantly decreased.
The replicative lifespans of sod1, sod2, uth1, and skn7 mutants of K6001 yeast were not affected by parishin.
We also found that parishin could decrease the gene expression of TORC1, ribosomal protein S26A (RPS26A), and ribosomal protein L9A (RPL9A) in the target of rapamycin (TOR) signaling pathway.
Gene expression levels of RPS26A and RPL9A in uth1, as well as in uth1, sir2 double mutants, were significantly lower than those of the control group.
Besides, TORC1 gene expression in uth1 mutant of K6001 yeast was inhibited significantly.
These results suggested that parishin exhibited antiaging effects via regulation of Sir2/Uth1/TOR signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Yanfei& Sun, Yujuan& Weng, Yufang& Matsuura, Akira& Xiang, Lan& Qi, Jianhua. 2016. Parishin from Gastrodia elata Extends the Lifespan of Yeast via Regulation of Sir2Uth1TOR Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113899
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Yanfei…[et al.]. Parishin from Gastrodia elata Extends the Lifespan of Yeast via Regulation of Sir2Uth1TOR Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113899
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Yanfei& Sun, Yujuan& Weng, Yufang& Matsuura, Akira& Xiang, Lan& Qi, Jianhua. Parishin from Gastrodia elata Extends the Lifespan of Yeast via Regulation of Sir2Uth1TOR Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113899
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113899
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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