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Metformin Prevents Renal Stone Formation through an Antioxidant Mechanism In Vitro and In Vivo
المؤلفون المشاركون
Yang, Xiong
Ding, Hao
Qin, Zhenbang
Zhang, Changwen
Qi, Shiyong
Zhang, Hongtuan
Yang, Tong
He, Zhen
Yang, Kuo
Du, E
Liu, Chunyu
Xu, Yong
Zhang, Zhihong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Oxidative stress is a causal factor and key promoter of urolithiasis associated with renal tubular epithelium cell injury.
The present study was designed to investigate the preventive effects of metformin on renal tubular cell injury induced by oxalate and stone formation in a hyperoxaluric rat model.
MTT assays were carried out to determine the protection of metformin from oxalate-induced cytotoxicity.
The intracellular superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were measured in vitro.
Male Sprague-Dawley rats were divided into control group, ethylene glycol (EG) treated group, and EG + metformin treated group.
Oxidative stress and crystal formations were evaluated in renal tissues after 8-week treatment.
Metformin significantly inhibited the decrease of the viability in MDCK cells and HK-2 cells induced by oxalate.
Besides, metformin markedly prevented the increased concentration of MDA and the decreased tendency of SOD in oxalate-induced MDCK cells and HK-2 cells.
In vivo, the increased MDA levels and the reduction of SOD activity were detected in the EG treated group compared with controls, while these parameters reversed in the EG + metformin treated group.
Kidney crystal formation in the EG + metformin treated group was decreased significantly compared with the EG treated group.
Metformin suppressed urinary crystal deposit formation through renal tubular cell protection and antioxidative effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiong& Ding, Hao& Qin, Zhenbang& Zhang, Changwen& Qi, Shiyong& Zhang, Hongtuan…[et al.]. 2016. Metformin Prevents Renal Stone Formation through an Antioxidant Mechanism In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiong…[et al.]. Metformin Prevents Renal Stone Formation through an Antioxidant Mechanism In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiong& Ding, Hao& Qin, Zhenbang& Zhang, Changwen& Qi, Shiyong& Zhang, Hongtuan…[et al.]. Metformin Prevents Renal Stone Formation through an Antioxidant Mechanism In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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