Comparative Analysis of the Interaction between Different Flavonoids and PDIA3
المؤلفون المشاركون
Giamogante, Flavia
Marrocco, Ilaria
Romaniello, Donatella
Eufemi, Margherita
Chichiarelli, Silvia
Altieri, Fabio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Flavonoids, plant secondary metabolites present in fruits, vegetables, and products such as tea and red wine, show antioxidant, anti-inflammatory, antithrombotic, antiviral, and antitumor activity.
PDIA3 is a member of the protein disulfide isomerase family mainly involved in the correct folding of newly synthetized glycoproteins.
PDIA3 is associated with different human pathologies such as cancer, prion disorders, Alzheimer’s disease, and Parkinson’s diseases and it has the potential to be a pharmacological target.
The interaction of different flavonoids with PDIA3 was investigated by quenching fluorescence analysis and the effects on protein activity were evaluated.
A higher affinity was observed for eupatorin-5-methyl ether and eupatorin which also inhibit reductase activity of PDIA3 but do not significantly affect its DNA binding activity.
The use of several flavonoids differing in chemical structure and functional groups allows us to make some consideration about the relationship between ligand structure and the affinity for PDIA3.
The specific flavone backbone conformation and the degree of polarity seem to play an important role for the interaction with PDIA3.
The binding site is probably similar but not equivalent to that of green tea catechins, which, as previously demonstrated, can bind to PDIA3 and prevent its interaction with DNA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giamogante, Flavia& Marrocco, Ilaria& Romaniello, Donatella& Eufemi, Margherita& Chichiarelli, Silvia& Altieri, Fabio. 2016. Comparative Analysis of the Interaction between Different Flavonoids and PDIA3. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113925
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giamogante, Flavia…[et al.]. Comparative Analysis of the Interaction between Different Flavonoids and PDIA3. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113925
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giamogante, Flavia& Marrocco, Ilaria& Romaniello, Donatella& Eufemi, Margherita& Chichiarelli, Silvia& Altieri, Fabio. Comparative Analysis of the Interaction between Different Flavonoids and PDIA3. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113925
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113925
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر