The Analgesic Effect of the Mitochondria-Targeted Antioxidant SkQ1 in Pancreatic Inflammation
المؤلفون المشاركون
Bazhin, Alexandr V.
Weniger, Maximilian
Reinelt, Leonard
Neumann, Jens
Holdt, Lesca
Ilmer, Matthias
Renz, Bernhard
Hartwig, Werner
D’Haese, Jan G.
Werner, Jens
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Chronic pancreatitis is one of the main risk factors for pancreatic cancer.
In acute and chronic pancreatitis, oxidative stress is thought to play a key role.
In this respect, the recently described mitochondria-targeted antioxidant SkQ1 effectively scavenges reactive oxygen species at nanomolar concentrations.
Therefore, we aimed to characterize the influence of SkQ1 on tissue injury and pain in acute and chronic pancreatitis.
Methods.
Both acute and chronic pancreatitis were induced in C57BL/6 mice by intraperitoneal cerulein injections and treatment with SkQ1 was carried out by peroral applications.
Hyperalgesia was assessed by behavioral observation and measurement of abdominal mechanical sensitivity.
Blood serum and pancreatic tissue were harvested for analysis of lipase and histology.
Results.
SkQ1 did not influence pain, serological, or histological parameters of tissue injury in acute pancreatitis.
In chronic pancreatitis, a highly significant reduction of pain-related behavior ( p < 0.0001 ) was evident, but histological grading revealed increased tissue injury in SkQ1-treated animals ( p = 0.03 ).
Conclusion.
After SkQ1 treatment, tissue injury is not ameliorated in acute pancreatitis and increased in chronic pancreatitis.
However, we show an analgesic effect in chronic pancreatitis.
Further studies will need to elucidate the risks and benefits of mitochondria-targeted antioxidants as an analgesic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weniger, Maximilian& Reinelt, Leonard& Neumann, Jens& Holdt, Lesca& Ilmer, Matthias& Renz, Bernhard…[et al.]. 2016. The Analgesic Effect of the Mitochondria-Targeted Antioxidant SkQ1 in Pancreatic Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113932
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weniger, Maximilian…[et al.]. The Analgesic Effect of the Mitochondria-Targeted Antioxidant SkQ1 in Pancreatic Inflammation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113932
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weniger, Maximilian& Reinelt, Leonard& Neumann, Jens& Holdt, Lesca& Ilmer, Matthias& Renz, Bernhard…[et al.]. The Analgesic Effect of the Mitochondria-Targeted Antioxidant SkQ1 in Pancreatic Inflammation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113932
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113932
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر