Relation between Endothelial Nitric Oxide Synthase Genotypes and Oxidative Stress Markers in Larynx Cancer
المؤلفون المشاركون
Verim, Aysegul
Çakatay, Ufuk
Atukeren, Pinar
Cacina, Canan
Turan, Saime
Yanar, K.
Aydın, S.
Özkan, N. E.
Karatoprak, K.
Cebe, T.
Ozkök, E.
Korkmaz, G.
Küçükhüseyin, O.
Yaylim, I.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nitric oxide synthase (eNOS/NOS3) is responsible for the endothelial synthesis of nitric oxide (NO•).
G894T polymorphism leads to the amino acid substitution from Glu298Asp that causes lower NOS3 activity and basal NO• production in NOS3 894T (298Asp) allele carriers compared with the GG homozygotes.
NO• acts as an antioxidant protecting against Fenton’s reaction which generates highly reactive hydroxyl radicals.
Allelic variation of NOS3 may influence an individual’s risk of laryngeal cancer (LC).
In the current study we have examined the possible relationship between NOS3 G894T genotypes and various systemic oxidative damage markers such as protein carbonyl, advanced oxidation protein products, Cu, Zn-superoxide dismutase, thiol group fractions, and lipid hydroperoxides in LC patients.
Genotyping was carried out by PCR-RFLP.
In LC patients with TT genotype, Cu, Zn-superoxide dismutase activities and nonprotein thiol levels were significantly higher than the controls.
In patients with GT and GG genotype, high levels of lipid hydroperoxides showed statistical significance when compared to controls.
Our results indicate a potential relationship among G894T polymorphism of NOS3, and impaired redox homeostasis.
Further studies are required to determine the role of NOS3 gene polymorphism and impaired plasma redox homeostasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yanar, K.& Çakatay, Ufuk& Aydın, S.& Verim, Aysegul& Atukeren, Pinar& Özkan, N. E.…[et al.]. 2015. Relation between Endothelial Nitric Oxide Synthase Genotypes and Oxidative Stress Markers in Larynx Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113977
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yanar, K.…[et al.]. Relation between Endothelial Nitric Oxide Synthase Genotypes and Oxidative Stress Markers in Larynx Cancer. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113977
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yanar, K.& Çakatay, Ufuk& Aydın, S.& Verim, Aysegul& Atukeren, Pinar& Özkan, N. E.…[et al.]. Relation between Endothelial Nitric Oxide Synthase Genotypes and Oxidative Stress Markers in Larynx Cancer. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113977
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113977
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر