![](/images/graphics-bg.png)
Polydatin Attenuates H2O2-Induced Oxidative Stress via PKC Pathway
المؤلفون المشاركون
Qiao, Huilian
Chen, Hao
Dong, Yuhang
Ma, He
Zhao, Guangchao
Tang, Fakuan
Li, Zhen
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Oxidative stress plays an important role in the pathogenesis of endothelial dysfunction, which is found to precede the development of diverse cardiovascular diseases (CVDs).
The aim of this study was to observe the protective effects of PD against H2O2-induced oxidative stress injury (OSI) in human umbilical vein endothelial cells (HUVECs) and the possible mechanism of PD in OSI treatment.
HUVECs were subjected to H2O2 in the absence or presence of PD.
It turned out that PD improved cell viability and adhesive and migratory abilities, inhibited the release of lactate dehydrogenase (LDH) and reactive oxygen species (ROS), and elevated the content of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD).
TUNEL, fluorometric assays, and Western blotting showed that OSI upregulated the apoptosis ratio, the activity of caspase-3 and the level of proapoptotic protein Bax and decreased the level of antiapoptotic protein Bcl-2.
However, PD treatment partially reversed these damage effects and Protein Kinase C (PKC) activation by thymeleatoxin (THX) in turn eliminated the antiapoptotic effect of PD.
Furthermore, PD attenuated the H2O2-induced phosphorylation of PKCs α and δ and increased the phosphorylation of PKC ε.
Our results indicated that PD might exert protective effects against OSI through various interactions with PKC pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qiao, Huilian& Chen, Hao& Dong, Yuhang& Ma, He& Zhao, Guangchao& Tang, Fakuan…[et al.]. 2016. Polydatin Attenuates H2O2-Induced Oxidative Stress via PKC Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qiao, Huilian…[et al.]. Polydatin Attenuates H2O2-Induced Oxidative Stress via PKC Pathway. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qiao, Huilian& Chen, Hao& Dong, Yuhang& Ma, He& Zhao, Guangchao& Tang, Fakuan…[et al.]. Polydatin Attenuates H2O2-Induced Oxidative Stress via PKC Pathway. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)