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Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor
المؤلفون المشاركون
Li, Xiaoran
Yue, Zhongjin
Lu, Jianzhong
Ma, Junhai
Shi, Wei
Su, Yu
Fu, Xu
Yang, Yanlin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To investigate whether calcium-sensing receptor (CaSR) plays a role in calcium-oxalate-induced renal injury.
Materials and Methods.
HK-2 cells and rats were treated with calcium oxalate (CaOx) crystals with or without pretreatment with the CaSR-specific agonist gadolinium chloride (GdCl3) or the CaSR-specific antagonist NPS2390.
Changes in oxidative stress (OS) in HK-2 cells and rat kidneys were assessed.
In addition, CaSR, extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal protein kinase (JNK), and p38 expression was determined.
Further, crystal adhesion assay was performed in vitro, and the serum urea and creatinine levels and crystal deposition in the kidneys were also examined.
Results.
CaOx increased CaSR, ERK, JNK, and p38 protein expression and OS in vitro and in vivo.
These deleterious changes were further enhanced upon pretreatment with the CaSR agonist GdCl3 but were attenuated by the specific CaSR inhibitor NPS2390 compared with CaOx treatment alone.
Pretreatment with GdCl3 further increased in vitro and in vivo crystal adhesion and renal hypofunction.
In contrast, pretreatment with NPS2390 decreased in vitro and in vivo crystal adhesion and renal hypofunction.
Conclusions.
CaOx-induced renal injury is related to CaSR-mediated OS and increased mitogen-activated protein kinase (MAPK) signaling, which subsequently leads to CaOx crystal adhesion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiaoran& Ma, Junhai& Shi, Wei& Su, Yu& Fu, Xu& Yang, Yanlin…[et al.]. 2016. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113992
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiaoran…[et al.]. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113992
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiaoran& Ma, Junhai& Shi, Wei& Su, Yu& Fu, Xu& Yang, Yanlin…[et al.]. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113992
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113992
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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