Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2Antioxidant Defense Pathways in a Rat Model
المؤلفون المشاركون
Orihuela-Campos, Rita Cristina
Fukui, Makoto
Ito, Hiro-O
Tamaki, Naofumi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The wound healing process attempts to restore the integrity and function of the injured tissue.
Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing.
The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes.
A circular excisional wound was created in the oral palatal region, and the wound healing process was observed.
The rats were divided into two experimental groups in which either hydrogen-rich water or distilled water was consumed.
In the drinking hydrogen-rich water, the palatal wound healing process was accelerated compared to that in the control group.
As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity.
Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors in rat palatal tissue.
In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway.
The results of this study support the hypothesis that oral administration of hydrogen-rich water benefits the wound healing process by decreasing oxidative stress and inflammatory responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tamaki, Naofumi& Orihuela-Campos, Rita Cristina& Fukui, Makoto& Ito, Hiro-O. 2015. Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2Antioxidant Defense Pathways in a Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114033
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tamaki, Naofumi…[et al.]. Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2Antioxidant Defense Pathways in a Rat Model. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114033
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tamaki, Naofumi& Orihuela-Campos, Rita Cristina& Fukui, Makoto& Ito, Hiro-O. Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2Antioxidant Defense Pathways in a Rat Model. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114033
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114033
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر