Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity
المؤلفون المشاركون
Ojha, Shreesh
Mohanraj, Rajesh
Goyal, Sameer N.
Al Taee, Hasan
Mahajan, Umesh B.
Patil, Chandrgouda R.
Arya, Dharmveer S.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-23
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Doxorubicin (DOX) is a potent and widely used anthracycline antibiotic for the treatment of several malignancies.
Unfortunately, the clinical utility of DOX is often restricted due to the elicitation of organ toxicity.
Particularly, the increased risk for the development of dilated cardiomyopathy by DOX among the cancer survivors warrants major attention from the physicians as well as researchers to develop adjuvant agents to neutralize the noxious effects of DOX on the healthy myocardium.
Despite these pitfalls, the use of traditional cytotoxic drugs continues to be the mainstay treatment for several types of cancer.
Recently, phytochemicals have gained attention for their anticancer, chemopreventive, and cardioprotective activities.
The ideal cardioprotective agents should not compromise the clinical efficacy of DOX and should be devoid of cumulative or irreversible toxicity on the naïve tissues.
Furthermore, adjuvants possessing synergistic anticancer activity and quelling of chemoresistance would significantly enhance the clinical utility in combating DOX-induced cardiotoxicity.
The present review renders an overview of cardioprotective effects of plant-derived small molecules and their purported mechanisms against DOX-induced cardiotoxicity.
Phytochemicals serve as the reservoirs of pharmacophore which can be utilized as templates for developing safe and potential novel cardioprotective agents in combating DOX-induced cardiotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ojha, Shreesh& Al Taee, Hasan& Goyal, Sameer N.& Mahajan, Umesh B.& Patil, Chandrgouda R.& Arya, Dharmveer S.…[et al.]. 2016. Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114042
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ojha, Shreesh…[et al.]. Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1114042
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ojha, Shreesh& Al Taee, Hasan& Goyal, Sameer N.& Mahajan, Umesh B.& Patil, Chandrgouda R.& Arya, Dharmveer S.…[et al.]. Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114042
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114042
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر