The Beneficial Effects of Renal Transplantation on Altered Oxidative Status of ESRD Patients
المؤلفون المشاركون
Miranda-Díaz, Alejandra Guillermina
Andrade-Sierra, Jorge
Carrillo-Ibarra, Sandra
Cerrillos-Gutiérrez, José Ignacio
Rojas-Campos, Enrique
Gómez-Navarro, Benjamín
Sifuentes-Franco, Sonia
Preciado-Rojas, Priscila
Cueto-Manzano, Alfonso Martín
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Renal transplantation (RT), has been considered the best therapeutic option for end stage renal disease (ESRD).
Objective.
To determine the effect of RT on the evolution of oxidative DNA status.
Methods.
Prospective cohort ( N = 50 receptors of RT); genotoxic damage, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and DNA repair enzyme, human 8-oxoguanine-DNA-N- glycosylase-1 (hOGG1); and antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GPx), were evaluated.
Results.
Before RT, 8-OHdG were significantly elevated ( 11.04 ± 0.90 versus 4.73 ± 0.34 ng/mL) compared to healthy controls ( p = 0.001 ), with normalization after 6 months of 4.78 ± 0.34 ng/mL ( p < 0.001 ).
The same phenomenon was observed with hOGG1 enzyme before RT with 2.14 ± 0.36 ng/mL ( p = 0.01 ) and decreased significantly at the end of the study to 1.20 ng/mL ( p < 0.001 ) but was higher than controls, 0.51 ± 0.07 ng/mL ( p < 0.03 ).
Antioxidant SOD was elevated at 24.09 ± 1.6 IU/mL versus healthy controls ( p = 0.001 ) before RT; however, 6 months after RT it decreased significantly to 16.9 ± 1.6 IU/mL ( p = 0.002 ), without achieving the levels of healthy controls ( p = 0.01 ).
The GPx, before RT, was significantly diminished with 24.09 ± 1.6 IU/mL versus healthy controls (39.0 ± 1.58) ( p = 0.01 ), while, in the final results, levels increased significantly to 30.38 ± 3.16 IU/mL ( p = 0.001 ).
Discussion.
Patients with ESRD have important oxidative damage before RT.
The RT significantly reduces oxidative damage and partially regulates the antioxidant enzymes (SOD and GPx).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cerrillos-Gutiérrez, José Ignacio& Miranda-Díaz, Alejandra Guillermina& Preciado-Rojas, Priscila& Gómez-Navarro, Benjamín& Sifuentes-Franco, Sonia& Carrillo-Ibarra, Sandra…[et al.]. 2016. The Beneficial Effects of Renal Transplantation on Altered Oxidative Status of ESRD Patients. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114047
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cerrillos-Gutiérrez, José Ignacio…[et al.]. The Beneficial Effects of Renal Transplantation on Altered Oxidative Status of ESRD Patients. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1114047
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cerrillos-Gutiérrez, José Ignacio& Miranda-Díaz, Alejandra Guillermina& Preciado-Rojas, Priscila& Gómez-Navarro, Benjamín& Sifuentes-Franco, Sonia& Carrillo-Ibarra, Sandra…[et al.]. The Beneficial Effects of Renal Transplantation on Altered Oxidative Status of ESRD Patients. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114047
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114047
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر