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Band 3 Erythrocyte Membrane Protein Acts as Redox Stress Sensor Leading to Its Phosphorylation by p72 Syk
المؤلفون المشاركون
Mandili, Giorgia
Khadjavi, Amina
Pantaleo, Antonella
Ferru, Emanuela
Pau, Maria Carmina
Spano, Alessandra
Pippia, Proto
Turrini, Francesco
Matte, Alessandro
De Franceschi, Lucia
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
In erythrocytes, the regulation of the redox sensitive Tyr phosphorylation of band 3 and its functions are still partially defined.
A role of band 3 oxidation in regulating its own phosphorylation has been previously suggested.
The current study provides evidences to support this hypothesis: (i) in intact erythrocytes, at 2 mM concentration of GSH, band 3 oxidation, and phosphorylation, Syk translocation to the membrane and Syk phosphorylation responded to the same micromolar concentrations of oxidants showing identical temporal variations; (ii) the Cys residues located in the band 3 cytoplasmic domain are 20-fold more reactive than GSH; (iii) disulfide linked band 3 cytoplasmic domain docks Syk kinase; (iv) protein Tyr phosphatases are poorly inhibited at oxidant concentrations leading to massive band 3 oxidation and phosphorylation.
We also observed that hemichromes binding to band 3 determined its irreversible oxidation and phosphorylation, progressive hemolysis, and serine hyperphosphorylation of different cytoskeleton proteins.
Syk inhibitor suppressed the phosphorylation of band 3 also preventing serine phosphorylation changes and hemolysis.
Our data suggest that band 3 acts as redox sensor regulating its own phosphorylation and that hemichromes leading to the protracted phosphorylation of band 3 may trigger a cascade of events finally leading to hemolysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pantaleo, Antonella& Ferru, Emanuela& Pau, Maria Carmina& Khadjavi, Amina& Mandili, Giorgia& Matte, Alessandro…[et al.]. 2015. Band 3 Erythrocyte Membrane Protein Acts as Redox Stress Sensor Leading to Its Phosphorylation by p72 Syk. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pantaleo, Antonella…[et al.]. Band 3 Erythrocyte Membrane Protein Acts as Redox Stress Sensor Leading to Its Phosphorylation by p72 Syk. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pantaleo, Antonella& Ferru, Emanuela& Pau, Maria Carmina& Khadjavi, Amina& Mandili, Giorgia& Matte, Alessandro…[et al.]. Band 3 Erythrocyte Membrane Protein Acts as Redox Stress Sensor Leading to Its Phosphorylation by p72 Syk. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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