Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2

المؤلفون المشاركون

Zhang, Jia-Qing
Gao, Bin-Wen
Wang, Jing
Ren, Qiao-Ling
Chen, Jun-Feng
Ma, Qiang
Zhang, Zi-Jing
Xing, Bao-Song

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-01-19

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الأحياء

الملخص EN

Reactive oxygen species (ROS) are closely related to the follicular granulosa cell apoptosis.

Grape seed procyanidin B2 (GSPB2) has been reported to possess potent antioxidant activity.

However, the GSPB2-mediated protective effects and the underlying molecular mechanisms in granulosa cell apoptosis process remain unknown.

In this study, we showed for the first time that GSPB2 treatment decreased FoxO1 protein level, improved granulosa cell viability, upregulated LC3-II protein level, and reduced granulosa cell apoptosis rate.

Under a condition of oxidative stress, GSPB2 reversed FoxO1 nuclear localization and increased its level in cytoplasm.

In addition, FoxO1 knockdown inhibited the protective effects of GSPB2 induced.

Our findings suggest that FoxO1 plays a pivotal role in regulating autophagy in granulosa cells, GSPB2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducing autophagy process, and targeting FoxO1 could be significant in fighting against oxidative stress-reduced female reproductive system diseases.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Jia-Qing& Gao, Bin-Wen& Wang, Jing& Ren, Qiao-Ling& Chen, Jun-Feng& Ma, Qiang…[et al.]. 2016. Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1114087

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Jia-Qing…[et al.]. Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1114087

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Jia-Qing& Gao, Bin-Wen& Wang, Jing& Ren, Qiao-Ling& Chen, Jun-Feng& Ma, Qiang…[et al.]. Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1114087

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1114087