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Activation of ALDH2 with Low Concentration of Ethanol Attenuates Myocardial IschemiaReperfusion Injury in Diabetes Rat Model
المؤلفون المشاركون
Kang, Pin-Fang
Wang, Hong-Ju
Gao, Qin
Wu, Wen-Juan
Tang, Yang
Xuan, Ling
Guan, Su-Dong
Tang, Bi
Zhang, Heng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The aim of this paper is to observe the change of mitochondrial aldehyde dehydrogenase 2 (ALDH2) when diabetes mellitus (DM) rat heart was subjected to ischemia/reperfusion (I/R) intervention and analyze its underlying mechanisms.
DM rat hearts were subjected to 30 min regional ischemia and 120 min reperfusion in vitro and pretreated with ALDH2 activator ethanol (EtOH); cardiomyocyte in high glucose (HG) condition was pretreated with ALDH2 activator Alda-1.
In control I/R group, myocardial tissue structure collapse appeared.
Compared with control I/R group, left ventricular parameters, SOD activity, the level of Bcl-2/Bax mRNA, ALDH2 mRNA, and protein expressions were decreased and LDH and MDA contents were increased, meanwhile the aggravation of myocardial structure injury in DM I/R group.
When DM I/R rats were pretreated with EtOH, left ventricular parameters, SOD, Bcl-2/Bax, and ALDH2 expression were increased; LDH, MDA, and myocardial structure injury were attenuated.
Compared with DM + EtOH I/R group, cyanamide (ALDH2 nonspecific blocker), atractyloside (mitoPTP opener), and wortmannin (PI3K inhibitor) groups all decreased left ventricular parameters, SOD, Bcl-2/Bax, and ALDH2 and increased LDH, MDA, and myocardial injury.
When cardiomyocyte was under HG condition, CCK-8 activity and ALDH2 protein expression were decreased.
Alda-1 increased CCK-8 and ALDH2.
Our findings suggested enhanced ALDH2 expression in diabetic I/R rats played the cardioprotective role, maybe through activating PI3K and inhibiting mitoPTP opening.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Pin-Fang& Wu, Wen-Juan& Tang, Yang& Xuan, Ling& Guan, Su-Dong& Tang, Bi…[et al.]. 2016. Activation of ALDH2 with Low Concentration of Ethanol Attenuates Myocardial IschemiaReperfusion Injury in Diabetes Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Pin-Fang…[et al.]. Activation of ALDH2 with Low Concentration of Ethanol Attenuates Myocardial IschemiaReperfusion Injury in Diabetes Rat Model. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Pin-Fang& Wu, Wen-Juan& Tang, Yang& Xuan, Ling& Guan, Su-Dong& Tang, Bi…[et al.]. Activation of ALDH2 with Low Concentration of Ethanol Attenuates Myocardial IschemiaReperfusion Injury in Diabetes Rat Model. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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