CD36Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice

المؤلفون المشاركون

Rabelo, Luíza A.
Souza dos Santos, Robson Augusto
Nunes-Souza, Valéria
Alenina, Natalia
Qadri, Fatimunnisa
Penninger, Josef M.
Bader, Michael

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-12-22

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Background and Aims.

Angiotensin converting enzyme 2 (ACE2) is an important component of the renin-angiotensin system.

Since angiotensin peptides have been shown to be involved in hepatic steatosis, we aimed to evaluate the hepatic lipid profile in ACE2-deficient (ACE 2 - / y ) mice.

Methods.

Male C57BL/6 and ACE 2 - / y mice were analyzed at the age of 3 and 6 months for alterations in the lipid profiles of plasma, faeces, and liver and for hepatic steatosis.

Results.

ACE 2 - / y mice showed lower body weight and white adipose tissue at all ages investigated.

Moreover, these mice had lower levels of cholesterol, triglycerides, and nonesterified fatty acids in plasma.

Strikingly, ACE 2 - / y mice showed high deposition of lipids in the liver.

Expression of CD36, a protein involved in the uptake of triglycerides in liver, was increased in ACE 2 - / y mice.

Concurrently, these mice exhibited an increase in hepatic oxidative stress, evidenced by increased lipid peroxidation and expression of uncoupling protein 2, and downregulation of sirtuin 1.

ACE 2 - / y mice also showed impairments in glucose metabolism and insulin signaling in the liver.

Conclusions.

Deletion of ACE2 causes CD36/sirtuin 1 axis impairment and thereby interferes with lipid homeostasis, leading to lipodystrophy and steatosis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nunes-Souza, Valéria& Alenina, Natalia& Qadri, Fatimunnisa& Penninger, Josef M.& Souza dos Santos, Robson Augusto& Bader, Michael…[et al.]. 2016. CD36Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114120

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nunes-Souza, Valéria…[et al.]. CD36Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114120

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nunes-Souza, Valéria& Alenina, Natalia& Qadri, Fatimunnisa& Penninger, Josef M.& Souza dos Santos, Robson Augusto& Bader, Michael…[et al.]. CD36Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114120

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1114120