The H2S Donor NaHS Changes the Expression Pattern of H2S-Producing Enzymes after Myocardial Infarction
المؤلفون المشاركون
Jin, Sheng
Hou, Cui-Lan
Ma, Fen-Fen
Wang, Ming-Jie
Zhu, Yi-Chun
Li, Xinghui
Li, Na
Bai, Ya-Dan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Aims.
To examine the expression patterns of hydrogen sulphide- (H2S-) producing enzymes in ischaemic heart tissue and plasma levels of H2S after 2 weeks of NaHS treatment after myocardial infarction (MI) and to clarify the role of endogenous H2S in the MI process.
Results.
After MI surgery, 2 weeks of treatment with the H2S donor NaHS alleviated ischaemic injury.
Meanwhile, in ischemia myocardium, three H2S-producing enzymes, cystathionine γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) significantly increased.
Plasma H2S levels were also elevated.
In vitro, NaHS treatment protected cardiomyocytes from hypoxic injury and raised CBS levels in a concentration-dependent manner.
Different from in vivo results, however, CSE or 3-MST expression did not change.
NaHS treatment increased the activity of CSE/CBS but not of 3-MST.
When CSE was either knocked down (in vitro) or knocked out (in vivo), H2S levels significantly decreased, which subsequently exacerbated the ischaemic injury.
Meanwhile, the expressions of CBS and 3-MST increased due to compensation.
Conclusions.
Exogenous H2S treatment changed the expressions of three H2S-producing enzymes and H2S levels after MI, suggesting a new and indirect regulatory mechanism for H2S production and its contribution to cardiac protection.
Endogenous H2S plays an important role in protecting ischaemic tissue after MI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Na& Wang, Ming-Jie& Jin, Sheng& Bai, Ya-Dan& Hou, Cui-Lan& Ma, Fen-Fen…[et al.]. 2016. The H2S Donor NaHS Changes the Expression Pattern of H2S-Producing Enzymes after Myocardial Infarction. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114121
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Na…[et al.]. The H2S Donor NaHS Changes the Expression Pattern of H2S-Producing Enzymes after Myocardial Infarction. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114121
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Na& Wang, Ming-Jie& Jin, Sheng& Bai, Ya-Dan& Hou, Cui-Lan& Ma, Fen-Fen…[et al.]. The H2S Donor NaHS Changes the Expression Pattern of H2S-Producing Enzymes after Myocardial Infarction. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114121
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114121
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر